TY - JOUR
T1 - The epidemiology of non-albicans Candida in oropharyngeal candidiasis in HIV patients
AU - Redding, Spencer W.
AU - Kirkpatrick, William R.
AU - Did, Olga
AU - Fothergill, Annette W.
AU - Rinaldi, Michael G.
AU - Patterson, Thomas F.
PY - 2000
Y1 - 2000
N2 - Oropharyngeal candidiasis (OPC) is the most common fungal infection in patients with HIV infection. Fluconazole has been proven to be very effective in treating this infection, but decreased susceptibility of Candida to this drug has emerged. Certain non-albicans species such as C. glabrata and C. krusei are commonly less susceptible to fluconazole than C. albicans and are being isolated with increased frequency in HIV patients. The purpose of this study was to determine if the presence of non-albicans Candida with OPC in HIV patients had an impact on clinical presentation. This study shows that late-stage HIV patients have a high prevalence of Candida with decreased susceptibility to fluconazole, especially non-albicans species. OPC episodes with non-albicans isolates were more likely to require higher doses of fluconazole to achieve clinical cure. Also, the presence of non-albicans Candida was more frequently associated with severe symptoms.
AB - Oropharyngeal candidiasis (OPC) is the most common fungal infection in patients with HIV infection. Fluconazole has been proven to be very effective in treating this infection, but decreased susceptibility of Candida to this drug has emerged. Certain non-albicans species such as C. glabrata and C. krusei are commonly less susceptible to fluconazole than C. albicans and are being isolated with increased frequency in HIV patients. The purpose of this study was to determine if the presence of non-albicans Candida with OPC in HIV patients had an impact on clinical presentation. This study shows that late-stage HIV patients have a high prevalence of Candida with decreased susceptibility to fluconazole, especially non-albicans species. OPC episodes with non-albicans isolates were more likely to require higher doses of fluconazole to achieve clinical cure. Also, the presence of non-albicans Candida was more frequently associated with severe symptoms.
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U2 - 10.1111/j.1754-4505.2000.tb00015.x
DO - 10.1111/j.1754-4505.2000.tb00015.x
M3 - Article
C2 - 11203894
AN - SCOPUS:0034276835
VL - 20
SP - 178
EP - 181
JO - Special Care in Dentistry
JF - Special Care in Dentistry
SN - 0275-1879
IS - 5
ER -