The eNOS gene: A candidate for the preeclampsia susceptibility locus?

Jennifer A. Lade, Eric K. Moses, Guanglan Guo, Alan N. Wilton, Madonna Grehan, Desmond W. Cooper, Shaun P. Brennecke

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: To investigate the endothelial cell nitric oxide synthase (eNOS) gene as a candidate for susceptibility to preeclampsia. Methods: Twenty-six Australian families containing 11 eclamptics, 59 severe preeclamptics, and 27 mild preeclamptics were used to test for linkage between the eNOS gene region and preeclampsia. Two microsatellite markers (D7S483 and D7S505) in the proximity of the eNOS gene were used. Main Outcome Measures: Logarithm of odds (LOD) scores were used to examine the cosegregation of alleles with the disease under a variety of inheritance models. Model-independent analysis, affected pedigree member method (AFFPED), and pairwise haplotype sharing between affected sibs were also used. Results: Two-point LOD score analysis gave no evidence of linkage between preeclampsia and two markers in close proximity to the eNOS gene (LOD scores < 1) for any of the inheritance models investigated, with no evidence of heterogeneity between pedigrees. The AFFPED and the pairwise haplotype sharing test on affected sibs also gave no evidence of linkage (p-values > 0.05). Conclusion: This study provides no evidence for linkage between two markers in close proximity to the eNOS gene and preeclampsia in these families. These results do not support the recent suggestion that eNOS could be a familial pregnancy-induced hypertension gene. Distinguishing preeclampsia from other hypertensive disorders in pregnancy is difficult. Hypertension appears to be a consequence, rather than a primary cause of preeclampsia. Given the vasodilatory role of the eNOS gene product, it is possible that the linkage recently reported for eNOS reflects its relationship with hypertension rather than preeclampsia.

Original languageEnglish (US)
Pages (from-to)81-93
Number of pages13
JournalHypertension in Pregnancy
Volume18
Issue number1
StatePublished - 1999
Externally publishedYes

Fingerprint

Nitric Oxide Synthase Type III
Pre-Eclampsia
Endothelial Cells
Genes
Hypertension
Pregnancy Induced Hypertension
Pedigree
Microsatellite Repeats
Haplotypes
Alleles
Outcome Assessment (Health Care)
Pregnancy

Keywords

  • Candidate gene
  • eNOS
  • Genetics
  • Linkage
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Internal Medicine

Cite this

Lade, J. A., Moses, E. K., Guo, G., Wilton, A. N., Grehan, M., Cooper, D. W., & Brennecke, S. P. (1999). The eNOS gene: A candidate for the preeclampsia susceptibility locus? Hypertension in Pregnancy, 18(1), 81-93.

The eNOS gene : A candidate for the preeclampsia susceptibility locus? / Lade, Jennifer A.; Moses, Eric K.; Guo, Guanglan; Wilton, Alan N.; Grehan, Madonna; Cooper, Desmond W.; Brennecke, Shaun P.

In: Hypertension in Pregnancy, Vol. 18, No. 1, 1999, p. 81-93.

Research output: Contribution to journalArticle

Lade, JA, Moses, EK, Guo, G, Wilton, AN, Grehan, M, Cooper, DW & Brennecke, SP 1999, 'The eNOS gene: A candidate for the preeclampsia susceptibility locus?', Hypertension in Pregnancy, vol. 18, no. 1, pp. 81-93.
Lade JA, Moses EK, Guo G, Wilton AN, Grehan M, Cooper DW et al. The eNOS gene: A candidate for the preeclampsia susceptibility locus? Hypertension in Pregnancy. 1999;18(1):81-93.
Lade, Jennifer A. ; Moses, Eric K. ; Guo, Guanglan ; Wilton, Alan N. ; Grehan, Madonna ; Cooper, Desmond W. ; Brennecke, Shaun P. / The eNOS gene : A candidate for the preeclampsia susceptibility locus?. In: Hypertension in Pregnancy. 1999 ; Vol. 18, No. 1. pp. 81-93.
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