TY - JOUR
T1 - The endonuclease IV family of apurinic/apyrimidinic endonucleases
AU - Daley, James M.
AU - Zakaria, Chadi
AU - Ramotar, Dindial
N1 - Funding Information:
J.M.D. was supported by a post-doctoral fellowship from the Le Fonds Québécois de la Recherche sur la Nature et les Technologies . This work was supported by funding from the Natural Sciences and Engineering Council of Canada (grant # 202432-01 ) to D.R.
PY - 2010/12
Y1 - 2010/12
N2 - Apurinic/apyrimidinic (AP) endonucleases are versatile DNA repair enzymes that possess a variety of nucleolytic activities, including endonuclease activity at AP sites, 3′ phosphodiesterase activity that can remove a variety of ligation-blocking lesions from the 3′ end of DNA, endonuclease activity on oxidative DNA lesions, and 3′ to 5′ exonuclease activity. There are two families of AP endonucleases, named for the bacterial counterparts endonuclease IV (EndoIV) and exonuclease III (ExoIII). While ExoIII family members are present in all kingdoms of life, EndoIV members exist in lower organisms but are curiously absent in plants, mammals and some other vertebrates. Here, we review recent research on these enzymes, focusing primarily on the EndoIV family. We address the role(s) of EndoIV members in DNA repair and discuss recent findings from each model organism in which the enzymes have been studied to date.
AB - Apurinic/apyrimidinic (AP) endonucleases are versatile DNA repair enzymes that possess a variety of nucleolytic activities, including endonuclease activity at AP sites, 3′ phosphodiesterase activity that can remove a variety of ligation-blocking lesions from the 3′ end of DNA, endonuclease activity on oxidative DNA lesions, and 3′ to 5′ exonuclease activity. There are two families of AP endonucleases, named for the bacterial counterparts endonuclease IV (EndoIV) and exonuclease III (ExoIII). While ExoIII family members are present in all kingdoms of life, EndoIV members exist in lower organisms but are curiously absent in plants, mammals and some other vertebrates. Here, we review recent research on these enzymes, focusing primarily on the EndoIV family. We address the role(s) of EndoIV members in DNA repair and discuss recent findings from each model organism in which the enzymes have been studied to date.
KW - Base excision repair
KW - C. elegans
KW - Endonucleases
KW - Genomic stability
KW - Nucleotide incision repair
KW - Yeast
UR - http://www.scopus.com/inward/record.url?scp=78649335598&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78649335598&partnerID=8YFLogxK
U2 - 10.1016/j.mrrev.2010.07.003
DO - 10.1016/j.mrrev.2010.07.003
M3 - Review article
C2 - 20667510
AN - SCOPUS:78649335598
VL - 705
SP - 217
EP - 227
JO - Mutation Research - Reviews in Mutation Research
JF - Mutation Research - Reviews in Mutation Research
SN - 1383-5742
IS - 3
ER -