The Endocannabinoid System and Parkinson Disease

Andrea Giuffrida, Alex Martinez

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Dysregulation of the endocannabinoid system has been implicated in several neurodegenerative disorders including Parkinson disease (PD). Within the motor areas of the brain, cannabinoid and dopamine systems regulate motor function and synaptic plasticity by modulating excitatory and inhibitory neurotransmission. Alterations of this cross talk have been linked to the pathophysiology of PD and the maladaptive plasticity associated with the disabling motor complications caused by long-term use of L-DOPA. This chapter reviews the complex functional interactions between endocannabinoid and dopaminergic/glutamatergic systems in the basal ganglia, the contribution of endocannabinoid transmission dysfunction to PD and L-DOPA-induced dyskinesia, and recent preclinical studies using cannabinoid-based drugs for the pharmacotherapy of these pathologic conditions.

Original languageEnglish (US)
Title of host publicationThe Endocannabinoid System
Subtitle of host publicationGenetics, Biochemistry, Brain Disorders, and Therapy
PublisherElsevier Inc.
Pages63-81
Number of pages19
ISBN (Electronic)9780128096673
ISBN (Print)9780128096666
DOIs
StatePublished - May 16 2017

Keywords

  • Basal ganglia
  • Cannabinoid receptors
  • Endocannabinoids
  • L-DOPA-induced dyskinesia
  • Neurodegeneration

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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