TY - JOUR
T1 - The Emerging Role of Left Bundle Branch Area Pacing for Cardiac Resynchronisation Therapy
AU - Diaz, Juan Carlos
AU - Duque, Mauricio
AU - Aristizabal, Julian
AU - Marin, Jorge
AU - Niño, Cesar
AU - Bastidas, Oriana
AU - Ruiz, Luis Miguel
AU - Matos, Carlos D.
AU - Hoyos, Carolina
AU - Hincapie, Daniela
AU - Velasco, Alejandro
AU - Romero, Jorge E.
N1 - Publisher Copyright:
© 2023 The Author(s).
PY - 2023
Y1 - 2023
N2 - Cardiac resynchronisation therapy (CRT) reduces the risk of heart failure-related hospitalisations and all-cause mortality, as well as improving quality of life and functional status in patients with persistent heart failure symptoms despite optimal medical treatment and left bundle branch block. CRT has traditionally been delivered by implanting a lead through the coronary sinus to capture the left ventricular epicardium; however, this approach is associated with significant drawbacks, including a high rate of procedural failure, phrenic nerve stimulation, high pacing thresholds and lead dislodgement. Moreover, a significant proportion of patients fail to derive any significant benefit. Left bundle branch area pacing (LBBAP) has recently emerged as a suitable alternative to traditional CRT. By stimulating the cardiac conduction system physiologically, LBBAP can result in a more homogeneous left ventricular contraction and relaxation, thus having the potential to improve outcomes compared with conventional CRT strategies. In this article, the evidence supporting the use of LBBAP in patients with heart failure is reviewed.
AB - Cardiac resynchronisation therapy (CRT) reduces the risk of heart failure-related hospitalisations and all-cause mortality, as well as improving quality of life and functional status in patients with persistent heart failure symptoms despite optimal medical treatment and left bundle branch block. CRT has traditionally been delivered by implanting a lead through the coronary sinus to capture the left ventricular epicardium; however, this approach is associated with significant drawbacks, including a high rate of procedural failure, phrenic nerve stimulation, high pacing thresholds and lead dislodgement. Moreover, a significant proportion of patients fail to derive any significant benefit. Left bundle branch area pacing (LBBAP) has recently emerged as a suitable alternative to traditional CRT. By stimulating the cardiac conduction system physiologically, LBBAP can result in a more homogeneous left ventricular contraction and relaxation, thus having the potential to improve outcomes compared with conventional CRT strategies. In this article, the evidence supporting the use of LBBAP in patients with heart failure is reviewed.
KW - Heart failure
KW - cardiac resynchronisation therapy
KW - conduction system pacing
KW - heart failure-related hospitalisation
KW - left bundle branch area pacing
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U2 - 10.15420/aer.2023.15
DO - 10.15420/aer.2023.15
M3 - Review article
C2 - 38173800
AN - SCOPUS:85180312525
SN - 2050-3369
VL - 12
JO - Arrhythmia and Electrophysiology Review
JF - Arrhythmia and Electrophysiology Review
ER -