The effects of the phyllolitorin analogue [desTrp3,Leu8]phyllolitorin on scratching induced by bombesin and related peptides in rats

Mark D. Johnson; Mei Chuan Ko; Kevin S. Choo; John R. Traynor; Henry I. Mosberg; Norah N. Naughton; James H. Woods

doi:10.1016/S0006-8993(99)01708-4

The effects of the phyllolitorin analogue [desTrp³,Leu⁸]phyllolitorin on scratching induced by bombesin and related peptides in rats

Mark D. Johnson, Mei Chuan Ko, Kevin S. Choo, John R. Traynor, Henry I. Mosberg, Norah N. Naughton, James H. Woods

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp³,Leu⁸]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu⁸]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 μg) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism.

Original language	English (US)
Pages (from-to)	194-198
Number of pages	5
Journal	Brain Research
Volume	839
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(99)01708-4
State	Published - Aug 21 1999
Externally published	Yes

Keywords

Bombesin
Bombesin antagonist
GRP(18-27)
Neuromedin-C
Phyllolitorin
Scratching behavior

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
Neuroscience(all)
Developmental Biology

Access to Document

10.1016/S0006-8993(99)01708-4

Cite this

@article{32506bb868b04344a36fe1a8f27eee9a,

title = "The effects of the phyllolitorin analogue [desTrp3,Leu8]phyllolitorin on scratching induced by bombesin and related peptides in rats",

abstract = "Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp3,Leu8]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu8]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 μg) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism.",

keywords = "Bombesin, Bombesin antagonist, GRP(18-27), Neuromedin-C, Phyllolitorin, Scratching behavior",

author = "Johnson, {Mark D.} and Ko, {Mei Chuan} and Choo, {Kevin S.} and Traynor, {John R.} and Mosberg, {Henry I.} and Naughton, {Norah N.} and Woods, {James H.}",

note = "Funding Information: We would like to thank Brendan Hug, Kathy Lee, and John R. Omnaas for their technical support and hard work. This study is supported by USPHS Grant DA00254 and the Clinical Research Partnership Fund of the University of Michigan.",

year = "1999",

month = aug,

day = "21",

doi = "10.1016/S0006-8993(99)01708-4",

language = "English (US)",

volume = "839",

pages = "194--198",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - The effects of the phyllolitorin analogue [desTrp3,Leu8]phyllolitorin on scratching induced by bombesin and related peptides in rats

AU - Johnson, Mark D.

AU - Ko, Mei Chuan

AU - Choo, Kevin S.

AU - Traynor, John R.

AU - Mosberg, Henry I.

AU - Naughton, Norah N.

AU - Woods, James H.

N1 - Funding Information: We would like to thank Brendan Hug, Kathy Lee, and John R. Omnaas for their technical support and hard work. This study is supported by USPHS Grant DA00254 and the Clinical Research Partnership Fund of the University of Michigan.

PY - 1999/8/21

Y1 - 1999/8/21

N2 - Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp3,Leu8]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu8]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 μg) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism.

AB - Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp3,Leu8]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu8]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 μg) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism.

KW - Bombesin

KW - Bombesin antagonist

KW - GRP(18-27)

KW - Neuromedin-C

KW - Phyllolitorin

KW - Scratching behavior

UR - http://www.scopus.com/inward/record.url?scp=0033592048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033592048&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(99)01708-4

DO - 10.1016/S0006-8993(99)01708-4

M3 - Article

C2 - 10482814

AN - SCOPUS:0033592048

SN - 0006-8993

VL - 839

SP - 194

EP - 198

JO - Brain Research

JF - Brain Research

IS - 1

ER -