The effects of the phyllolitorin analogue [desTrp3,Leu8]phyllolitorin on scratching induced by bombesin and related peptides in rats

Mark D. Johnson, Mei Chuan Ko, Kevin S. Choo, John R. Traynor, Henry I. Mosberg, Norah N. Naughton, James H. Woods

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Bombesin along with several closely related neuropeptides elicit scratching behavior when administered centrally. The first part of the study was designed to determine the antagonistic effects of a novel phyllolitorin analogue [desTrp3,Leu8]phyllolitorin (DTP) on scratching induced by three peptides (bombesin, neuromedin-C, and [Leu8]phyllolitorin). In addition, the binding affinity of each peptide for the bombesin receptor site was determined. DTP (30 μg) inhibited scratching induced by these peptides, but unlike the peptides, DTP had no affinity for the bombesin site, thereby suggesting that DTP is displaying physiological antagonism through an unknown mechanism.

Original languageEnglish (US)
Pages (from-to)194-198
Number of pages5
JournalBrain Research
Volume839
Issue number1
DOIs
StatePublished - Aug 21 1999
Externally publishedYes

Keywords

  • Bombesin
  • Bombesin antagonist
  • GRP(18-27)
  • Neuromedin-C
  • Phyllolitorin
  • Scratching behavior

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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