The effects of repeated Ozurdex injections on ocular hypertension

Sepehr Bahadorani, Chelsey Krambeer, Kendall Wannamaker, Wayne Tie, Michael Jansen, Jason Espitia, Jeong Hyeon Sohn, Michael A. Singer

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Purpose: The purpose of this study was to correlate the degree of ocular hypertension with the number of Ozurdex injections. Methods: Intraocular pressure (IOP) fluctuations for a total of 183 injections were studied over a period of at least 12 months. The main indications for treatment were uveitis, diabetic macular edema, and retinal vein occlusion. Results: Results of the study demonstrate that repeated Ozurdex injections do not increase the frequency of IOP spikes beyond 30 mmHg. For lower IOPs, however, a positive correlation exists. Furthermore, patients with primary open angle glaucoma and uveitis had the highest IOP response to repeated injections. On average, patients with an IOP of ≥28.6 mmHg received pressure lowering medications, after which their IOP reached a stable level (16.7 mmHg) without the need for additional interventions. Conclusion: The data support the conclusion that multiple Ozurdex injections does not increase the frequency of IOP spikes beyond 30 mmHg, but patients still must be closely monitored if they have a history of primary open angle glaucoma.

Original languageEnglish (US)
Pages (from-to)639-642
Number of pages4
JournalClinical Ophthalmology
Volume12
DOIs
StatePublished - Apr 3 2018

Keywords

  • Dexamethasone
  • Glaucoma
  • Intraocular pressure
  • Ocular hypertension
  • Ozurdex

ASJC Scopus subject areas

  • Ophthalmology

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    Bahadorani, S., Krambeer, C., Wannamaker, K., Tie, W., Jansen, M., Espitia, J., Sohn, J. H., & Singer, M. A. (2018). The effects of repeated Ozurdex injections on ocular hypertension. Clinical Ophthalmology, 12, 639-642. https://doi.org/10.2147/OPTH.S148990