The effects of regenerative injection therapy compared to corticosteroids for the treatment of lateral Epicondylitis: a systematic review and meta-analysis

Julie Barnett, Madison N. Bernacki, Jessica L. Kainer, Hannah N. Smith, Annette M. Zaharoff, Sandeep K. Subramanian

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Background: The lateral epicondyle is a common site for chronic tendinosis (i.e. lateral epicondylitis), a condition characterized by overuse and degeneration of a tendon due to repeated microtrauma. This leads to pain and functional limitations. There is a growing interest in non-surgical forms of treatment for this condition including provision of corticosteroid injections and regenerative injection therapy (provision of autologous blood and platelet rich plasma injections). Objective: We compared the effectiveness of corticosteroids with regenerative injection therapy for the treatment of lateral epicondylitis. Methods: We systematically reviewed randomized controlled trials published in English language from 2008 to 2018. Databases used included PEDro, Scopus, PubMed, and CINAHL. Nine articles met our selection criteria. The PEDRo scale scores helped assess study quality. Cochrane risk of bias criteria helped assess bias. We analyzed results focusing on pain and function using meta-analyses. Results: Six out of 9 studies had low risk of bias. There were no short-term (1 and 2 month) differences in pain scores between the corticosteroid and regenerative injection groups. Participants receiving regenerative injections demonstrated greater long-term improvements lasting for a period of ≈2 years. Conclusion: Regenerative injections provision results in greater long–term pain relief and improved function for people with lateral epicondylitis.

Original languageEnglish (US)
Article number12
JournalArchives of Physiotherapy
Volume9
Issue number1
DOIs
StatePublished - Dec 2019

Keywords

  • Autologous blood injection
  • Elbow
  • Enthesopathy
  • Platelet rich plasma
  • Tendinosis

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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