The effects of postnatal estrogen therapy on brain development in preterm baboons

Sandra Rees, Michelle Loeliger, Amy Shields, Philip W. Shaul, Donald McCurnin, Bradley Yoder, Terrie Inder

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective Estrogen receptors are present within the fetal brain, suggesting that estrogens may exert an influence on cerebral development. Loss of placentally derived estrogen in preterm birth may impair development. Study Design Baboons were delivered at 125 days of gestation (term approximately 185 days), randomly allocated to receive estradiol (n = 10) or placebo (n = 8), and ventilated for 14 days. Brains were assessed for developmental and neuropathological parameters. Results Body and brain weights were not different between groups, but the brain/body weight ratio was increased (P < .05) in estradiol-treated animals. There were no differences (P > .05) between groups in any neuropathological measure in either the forebrain or cerebellum. There were no intraventricular hemorrhages; 1 estradiol animal displayed ectactic vessels in the subarachnoid space. Conclusion Brief postnatal estradiol administration to primates does not pose an increased risk of injury or impaired brain development.

Original languageEnglish (US)
Pages (from-to)177.e8-177.e14
JournalAmerican Journal of Obstetrics and Gynecology
Volume204
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • baboon
  • brain development
  • brain injury
  • postnatal estradiol
  • premature delivery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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