TY - JOUR
T1 - The Effects of Platelet-Rich Plasma on Tendon and Ligament
T2 - Basic Science and Clinical Application
AU - Geaney, Lauren E.
AU - Arciero, Robert A.
AU - Deberardino, Thomas M.
AU - Mazzocca, Augustus D.
PY - 2011/9
Y1 - 2011/9
N2 - The introduction of platelet-rich plasma (PRP) as a possible adjunct to conservative and operative treatment has motivated significant research in the topic. Platelet growth factors within alpha granules are released upon activation. These growth factors regulate and enhance tendon healing, so an increase in platelet concentration at the site of injury would hypothetically increase the healing response. Laboratory and animal studies have shown encouraging results in the role and effect of PRP on tendon healing. Animal studies also show an increased strength of tendon repairs augmented with PRP. However, clinical trials have been less consistent. Some show an improvement in pain control and return to function, whereas others show no difference compared to controls. The purpose of this review was to describe the biology and clinical outcomes of PRP treatment of tendon and ligament injuries.
AB - The introduction of platelet-rich plasma (PRP) as a possible adjunct to conservative and operative treatment has motivated significant research in the topic. Platelet growth factors within alpha granules are released upon activation. These growth factors regulate and enhance tendon healing, so an increase in platelet concentration at the site of injury would hypothetically increase the healing response. Laboratory and animal studies have shown encouraging results in the role and effect of PRP on tendon healing. Animal studies also show an increased strength of tendon repairs augmented with PRP. However, clinical trials have been less consistent. Some show an improvement in pain control and return to function, whereas others show no difference compared to controls. The purpose of this review was to describe the biology and clinical outcomes of PRP treatment of tendon and ligament injuries.
KW - Ligament
KW - Platelet-rich plasma
KW - Tendon
UR - http://www.scopus.com/inward/record.url?scp=80052311518&partnerID=8YFLogxK
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U2 - 10.1053/j.otsm.2011.04.001
DO - 10.1053/j.otsm.2011.04.001
M3 - Article
AN - SCOPUS:80052311518
SN - 1060-1872
VL - 19
SP - 160
EP - 164
JO - Operative Techniques in Sports Medicine
JF - Operative Techniques in Sports Medicine
IS - 3
ER -