The effects of platelet-activating factor (PAF) and a PAF antagonist (CV-3988) on smoke inhalation injury in an ovine model

Hisashi Ikeuchi, Tsutomu Sakano, Jose Sanchez, Arthur D. Mason, Basil A. Pruitt

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The role of platelet-activating factor (PAF) in inhalation injury was studied in sheep, using CV-3988, a PAF antagonist. Following smoke exposure, 15 sheep were divided into three groups of five. Group I animals were untreated; group II animals were treated with CV-3988 before and after exposure; group III animals were treated only after exposure. In group I, platelet and WBC counts were markedly changed within 6 hours (p < 0.05); in the treated groups, alteration of cell counts was not obvious. Blood malondialdehyde (MDA) levels were increased significantly only in group I. Blood PGE2 and TXB2 levels did not differ among the groups. Mean tissue MDA and mean bronchoalveolar lavage fluid (BALF) MDA concentrations were significantly increased in group I (p < 0.01); mean BALF TXB2 levels were significantly decreased in group I (p < 0.01). These data suggest that PAF affects inhalation injury through modulation of lipid oxygenation and that PAF antagonists may offer therapeutic benefit in the management of this injury.

Original languageEnglish (US)
Pages (from-to)344-350
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume32
Issue number3
DOIs
StatePublished - Mar 1992

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Fingerprint Dive into the research topics of 'The effects of platelet-activating factor (PAF) and a PAF antagonist (CV-3988) on smoke inhalation injury in an ovine model'. Together they form a unique fingerprint.

  • Cite this