The Effects of Pentoxifylline on Pulmonary Function Following Smoke Inhalation

Hiroshi Ogura, William G. Cioffi, Carlin V. Okerberg, Avery A. Johnson, Rey F. Guzman, Arthur D. Mason, Basil A Pruitt

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Bronchopulmonary injury secondary to smoke inhalation is a significant comorbid factor following major thermal trauma. The present study evaluates the effects of pentoxifylline (PTX) on pulmonary function in art ovine model of inhalation injury. Following smoke exposure to produce a moderate inhalation injury, 16 animals were divided into two groups. Group 1 animals (n = 8) were untreated; Group 2 animals (n = 8) were treated continuously with pentoxifylline following smoke exposure. The animals were observed in the unintubated, awake state for 48 hr. Cardiopulmonary variables and blood gases were measured serially. Ventilation perfusion distribution (V̇A/Q̇), analyzed using the multiple inert gas elimination technique, and bronchoalveolar lavage (BAL) were performed at 48 hr. The wet to dry lung weight ratio was measured following necropsy. In Group 2, the progressive hypoxemia observed following smoke inhalation was attenuated with less V̇A /Q̇ mismatching than in Group 1 (P < 0.0.5). Pulmonary hypertension secondary to increased vascular resistance was also attenuated in Group 2 (P < 0.1)5). In BAL fluid, polymorphonuclear leukocytes, total protein content, and conjugated dienes were less in Group 2 than in Group 1 (P < 0.05). Plasma-conjugated diene levels were also lower in Group 2 at 48 hr. Extravascular lung water and decrease in lung compliance were greater in Group 1. There was less morphologic evidence of airway injury in Group 2 compared to Group 1. The improvement of pulmonary function following treatment with PTX suggest that this agent may be useful in the management of smoke inhalation injury.

Original languageEnglish (US)
Pages (from-to)242-250
Number of pages9
JournalJournal of Surgical Research
Volume56
Issue number3
DOIs
StatePublished - Mar 1994
Externally publishedYes

Fingerprint

Pentoxifylline
Smoke
Inhalation
Lung
Wounds and Injuries
Smoke Inhalation Injury
Extravascular Lung Water
Noble Gases
Lung Compliance
Bronchoalveolar Lavage Fluid
Bronchoalveolar Lavage
Art
Pulmonary Hypertension
Vascular Resistance
Ventilation
Sheep
Neutrophils
Perfusion
Hot Temperature
Gases

ASJC Scopus subject areas

  • Surgery

Cite this

Ogura, H., Cioffi, W. G., Okerberg, C. V., Johnson, A. A., Guzman, R. F., Mason, A. D., & Pruitt, B. A. (1994). The Effects of Pentoxifylline on Pulmonary Function Following Smoke Inhalation. Journal of Surgical Research, 56(3), 242-250. https://doi.org/10.1006/jsre.1994.1038

The Effects of Pentoxifylline on Pulmonary Function Following Smoke Inhalation. / Ogura, Hiroshi; Cioffi, William G.; Okerberg, Carlin V.; Johnson, Avery A.; Guzman, Rey F.; Mason, Arthur D.; Pruitt, Basil A.

In: Journal of Surgical Research, Vol. 56, No. 3, 03.1994, p. 242-250.

Research output: Contribution to journalArticle

Ogura, H, Cioffi, WG, Okerberg, CV, Johnson, AA, Guzman, RF, Mason, AD & Pruitt, BA 1994, 'The Effects of Pentoxifylline on Pulmonary Function Following Smoke Inhalation', Journal of Surgical Research, vol. 56, no. 3, pp. 242-250. https://doi.org/10.1006/jsre.1994.1038
Ogura H, Cioffi WG, Okerberg CV, Johnson AA, Guzman RF, Mason AD et al. The Effects of Pentoxifylline on Pulmonary Function Following Smoke Inhalation. Journal of Surgical Research. 1994 Mar;56(3):242-250. https://doi.org/10.1006/jsre.1994.1038
Ogura, Hiroshi ; Cioffi, William G. ; Okerberg, Carlin V. ; Johnson, Avery A. ; Guzman, Rey F. ; Mason, Arthur D. ; Pruitt, Basil A. / The Effects of Pentoxifylline on Pulmonary Function Following Smoke Inhalation. In: Journal of Surgical Research. 1994 ; Vol. 56, No. 3. pp. 242-250.
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