This study was undertaken to analyze the effects of significant hyperthermia (> 100°C) associated with the polymerization of polymethlymethacrylate (PMM) on the permeability of the cerebral vasculature in rats. The method used to visualize the pial vasculature included the open pial window technique and epifluorescence microscopy. Results indicated that there is a significant increase in cerebral vascular permeability following in situ polymerization of PMM over the craniectomy site.
- Cerebral vascular permeability
- Fluorescence isothiocyanate (FITC) albumin
ASJC Scopus subject areas
- Clinical Neurology