The effects of methylglyoxal on central synaptic transmission in the isolated nerve cord of the cockroach. (Periplaneta americana L).

P. L. Chambers, M. G. Davies, M. J. Rowan

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Methylglyoxal (10(-5) to 1.5 X 10(-4) M) was found to have excitatory effects on synaptic transmission in the isolated 6th abdominal ganglion of the cockroach. There was a concentration-dependent depolarization of the giant interneurones which was accompanied by an increase in the amplitude and duration of electrically evoked excitatory postsynaptic potentials. The frequency of spontaneous activity was also increased.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalArchives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
Volume8
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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