The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment

Amir Ghaderi, Hamid Reza Banafshe, Naghmeh Mirhosseini, Maryam Motmaen, Fatemeh Mehrzad, Fereshteh Bahmani, Esmat Aghadavod, Mohammad Ali Mansournia, Russel J. Reiter, Mohammad Amin Karimi, Zatollah Asemi

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

This investigation was designed to determine the effect of melatonin supplementation on mental health parameters, metabolic and genetic profiles in patients under methadone maintenance treatment (MMT). This randomized, double-blind, placebo-controlled, clinical trial was conducted among 54 patients under MMT. Participants were randomly allocated to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 26) or placebo (n = 28) once a day, 1 hour before bedtime for 12 weeks. Melatonin supplementation significantly decreased Pittsburgh Sleep Quality Index (β −4.08; 95 percent CI, −5.51, −2.65; P < 0.001), Beck Depression Inventory index (β −5.46; 95% CI, −8.92, −2.00; P = 0.003) and Beck Anxiety Inventory index (β −3.87; 95% CI, −5.96, −1.77; P = 0.001) and significantly increased International Index of Erectile Functions (β 5.59; 95% CI, 1.76, 9.42; P = 0.005) compared with the placebo. Subjects who received melatonin supplements had significantly lower serum insulin levels (β −2.53; 95% CI, −4.48, −0.59; P = 0.01), homeostasis model of assessment-insulin resistance (β −0.56; 95% CI, −1.03, −0.09; P = 0.01) and higher quantitative insulin sensitivity check index (β 0.01; 95% CI, 0.004, 0.02; P = 0.009) and HDL-cholesterol levels (β 3.71; 95% CI, 1.77, 5.64; P = 0.002) compared to placebo. Additionally, melatonin intake resulted in a significant reduction in serum high sensitivity C-reactive protein (β −0.15; 95% CI, −0.27, −0.02; P = 0.02), malondialdehyde (β −0.31; 95% CI, −0.57, −0.05; P = 0.02) and protein carbonyl (β −0.06; 95% CI, −0.09, −0.04; P < 0.001). This trial indicated that taking melatonin supplements for 12 weeks by patients under MMT had beneficial effects on their mental health metabolic profiles.

Original languageEnglish (US)
Pages (from-to)754-764
Number of pages11
JournalAddiction Biology
Volume24
Issue number4
DOIs
StatePublished - Jul 2019

Keywords

  • melatonin supplementation
  • mental health
  • metabolic profiles
  • methadone maintenance treatment

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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