The Effects of Hypertriglyceridemia on Plasma Free Hemoglobin Levels and Extracorporeal Membrane Oxygenation Support

Julia Dolores Ruiz, Veronica Armijo-Garcia

Research output: Contribution to journalArticlepeer-review

Abstract

Exposure of patients to significant hemolysis can lead to serious clinical sequelae. Plasma free hemoglobin (pFHgb) is used during extracorporeal membrane oxygenation (ECMO) support to monitor ongoing hemolysis that is a consequence of mechanical forces applied to the red blood cells. This publication presents the case of a 3-year-old child who required ECMO support due to severe pneumonia. During her ECMO course, she developed severe elevations of pFHgb that were of questionable validity. Additional laboratory findings suggested a concurrent hypertriglyceridemia to be the potential cause for these false elevations. Linear regression analysis was employed and revealed a statistically significant (P = .006) moderate correlation between pFHgb and triglyceride levels (R = .69). The analysis reinforces the theory that hypertriglyceridemia may lead to false increases in pFHgb, which may complicate a patient's clinical picture and influence management decisions. Therefore, it should not be the sole value used to assess hemolysis in patients on ECMO.

Original languageEnglish (US)
Pages (from-to)176-178
Number of pages3
JournalICU Director
Volume3
Issue number4
DOIs
StatePublished - Dec 1 2012

Keywords

  • extracorporeal membrane oxygenation (ECMO)
  • hemolysis
  • hypertriglyceridemia
  • plasma free hemoglobin

ASJC Scopus subject areas

  • Critical Care
  • Critical Care and Intensive Care Medicine
  • Management Science and Operations Research

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