TY - JOUR
T1 - The Effects of Ethanol on Cerebral Regional Acetylcholine Concentration and Utilization
AU - Parker, Telfair H.
AU - Roberts, Roderick K.
AU - Henderson, George I.
AU - Hoyumpa, Anastacio M.
AU - Schmidt, Dennis E.
AU - Schenker, Steven
N1 - Funding Information:
Supported by the Medical Research Service of the Veterans Administration, NIH Grant AA00267, a grant from the Distilled Spirits Council of the United States, and Vanderbilt University Grant BRSG RR-05424.
PY - 1978/11
Y1 - 1978/11
N2 - This study assessed the effect of alcohol, given as single increasing doses or chronically, on regional cerebral acetylcholine concentration. In the acute studies in both rats and mice, brain acetylcholine rose significantly, but modestly, at higher blood ethanol concentrations. This effect was most consistent in the corpus striatum. At low blood alcohol levels, when brain acetylcholine levels were unaltered, the utilization rate of acetylcholine decreased in all brain areas and this was statistically significant in the cortex and midbrain. By contrast, in rats exposed to chronic oral ethanol intake but studied when blood alcohol was normal, brain acetylcholine was unaltered. These data are most consistent with the concept that alcohol directly depresses neuronal function resulting in decreased release (utilization) of acetylcholine and at high alcohol concentrations induces a modest accumulation of acetylcholine in brain.
AB - This study assessed the effect of alcohol, given as single increasing doses or chronically, on regional cerebral acetylcholine concentration. In the acute studies in both rats and mice, brain acetylcholine rose significantly, but modestly, at higher blood ethanol concentrations. This effect was most consistent in the corpus striatum. At low blood alcohol levels, when brain acetylcholine levels were unaltered, the utilization rate of acetylcholine decreased in all brain areas and this was statistically significant in the cortex and midbrain. By contrast, in rats exposed to chronic oral ethanol intake but studied when blood alcohol was normal, brain acetylcholine was unaltered. These data are most consistent with the concept that alcohol directly depresses neuronal function resulting in decreased release (utilization) of acetylcholine and at high alcohol concentrations induces a modest accumulation of acetylcholine in brain.
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U2 - 10.3181/00379727-159-40330
DO - 10.3181/00379727-159-40330
M3 - Article
C2 - 568799
AN - SCOPUS:0018235264
VL - 159
SP - 270
EP - 275
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 1535-3702
IS - 2
ER -