The effects of drug and behavior therapy on urgency and voiding frequency

Kathryn L. Burgio, Stephen R. Kraus, Diane Borello-France, Toby C. Chai, Kimberly Kenton, Patricia S. Goode, Yan Xu, John W. Kusek

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Introduction and hypothesis: The objective of this study was to examine the effects of drug therapy alone and combined with behavioral therapy on urgency and 24-voiding frequency in women with urge-predominant incontinence and to identify predictors of change. Methods: A planned analysis of data from a multi-site, randomized, controlled trial (N=307). Bladder diaries were used to document voids, incontinence, and urgency severity. Results: Urgency scores decreased significantly within both treatment groups, but changes did not differ between groups (p=0.30). Improvement in urgency was associated with greater baseline urgency (p<0.0001) and black ethnicity (p=0.03). Voiding frequency increased with drug alone and decreased slightly with combined therapy (p=0.009), and improvement was associated with combined treatment (p<0.0001), higher baseline frequency (p<0.0001), and lower baseline incontinence episode frequency (p=0.001). Conclusions: Although combined drug and behavioral therapy does not appear to improve urgency more than drug alone, it resulted in better outcomes on voiding frequency.

Original languageEnglish (US)
Pages (from-to)711-719
Number of pages9
JournalInternational Urogynecology Journal
Issue number6
StatePublished - Jun 2010


  • Behavioral treatment
  • Drug therapy
  • Overactive bladder
  • Urge incontinence
  • Urinary frequency
  • Urinary urgency

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynecology


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