The effects of drug and behavior therapy on urgency and voiding frequency

Kathryn L. Burgio, Stephen R. Kraus, Diane Borello-France, Toby C. Chai, Kimberly Kenton, Patricia S. Goode, Yan Xu, John W. Kusek

Research output: Contribution to journalArticle

12 Scopus citations


Introduction and hypothesis: The objective of this study was to examine the effects of drug therapy alone and combined with behavioral therapy on urgency and 24-voiding frequency in women with urge-predominant incontinence and to identify predictors of change. Methods: A planned analysis of data from a multi-site, randomized, controlled trial (N=307). Bladder diaries were used to document voids, incontinence, and urgency severity. Results: Urgency scores decreased significantly within both treatment groups, but changes did not differ between groups (p=0.30). Improvement in urgency was associated with greater baseline urgency (p<0.0001) and black ethnicity (p=0.03). Voiding frequency increased with drug alone and decreased slightly with combined therapy (p=0.009), and improvement was associated with combined treatment (p<0.0001), higher baseline frequency (p<0.0001), and lower baseline incontinence episode frequency (p=0.001). Conclusions: Although combined drug and behavioral therapy does not appear to improve urgency more than drug alone, it resulted in better outcomes on voiding frequency.

Original languageEnglish (US)
Pages (from-to)711-719
Number of pages9
JournalInternational Urogynecology Journal
Issue number6
StatePublished - Jun 2010



  • Behavioral treatment
  • Drug therapy
  • Overactive bladder
  • Urge incontinence
  • Urinary frequency
  • Urinary urgency

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Urology

Cite this

Burgio, K. L., Kraus, S. R., Borello-France, D., Chai, T. C., Kenton, K., Goode, P. S., Xu, Y., & Kusek, J. W. (2010). The effects of drug and behavior therapy on urgency and voiding frequency. International Urogynecology Journal, 21(6), 711-719.