The effects of dihydroergotamine upon adenyl cyclase and phosphodiesterase of rat fat cells

Walter F. Ward, John N. Fain

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Dihydroergotamine potentiates the lipolytic effects of theophylline, but blocks lipolysis due to catecholamines. Dihydroergotamine was found to markedly inhibit soluble cyclic nucleotide phosphodiesterase of both brown and white fat cells. Catecholamine stimulation of the adenyl cyclase of fat cell ghosts was inhibited by dihydroergotamine, which had no effect upon basal or fluoride-stimulated adenyl cyclase activity.

Original languageEnglish (US)
Pages (from-to)387-390
Number of pages4
JournalBBA - General Subjects
Volume237
Issue number2
DOIs
StatePublished - May 18 1971

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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