Dihydroergotamine potentiates the lipolytic effects of theophylline, but blocks lipolysis due to catecholamines. Dihydroergotamine was found to markedly inhibit soluble cyclic nucleotide phosphodiesterase of both brown and white fat cells. Catecholamine stimulation of the adenyl cyclase of fat cell ghosts was inhibited by dihydroergotamine, which had no effect upon basal or fluoride-stimulated adenyl cyclase activity.
ASJC Scopus subject areas
- Molecular Biology