The effects of ammonium chloride on endothelial cell glycoconjugate synthesis

J. Erikson, A. Heifetz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The involvement of acidic cellular compartments that function in biosynthetic roles has recently become an important facet in understanding the regulation of glycoconjugate biosynthesis. Treating cells with increasing concentrations of ammonium chloride (1-50 mM) resulted in about a 50% increase in the synthesis and secretion of newly synthesized [3H]glucosamine-labeled and 35SO4-labeled endothelial glycoproteins. In contrast, these increasing concentrations of ammonium chloride resulted in a marked decrease in the synthesis of [3H]glucosamine- and 35SO4-labeled secreted proteoglycans. Thus the apparent neutralization of acidic compartments does not adversely effect glycoprotein biosynthesis.

Original languageEnglish (US)
Pages (from-to)1022-1023
Number of pages2
JournalIRCS Medical Science
Volume11
Issue number11
StatePublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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