The effects of a long-term physical activity intervention on serum uric acid in older adults at risk for physical disability

Kristen M. Beavers, Fang Chi Hsu, Monica C. Serra, Veronica Yank, Marco Pahor, Barbara J. Nicklas

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Observational studies show a relationship between elevated serum uric acid (UA) and better physical performance and muscle function. The purpose of this paper was to determine whether regular participation in an exercise intervention, known to improve physical functioning, would result in increased serum UA. For this study, 424 older adults at risk for physical disability were randomized to participate in either a 12-mo moderate-intensity physical activity (PA) or a successful aging (SA) health education intervention. UA was measured at baseline, 6, and 12 mo (n = 368, 341, and 332, respectively). Baseline UA levels were 6.03 × 1.52 mg/dl and 5.94 × 1.55 mg/dl in the PA and SA groups, respectively. The adjusted mean UA at month 12 was 4.8% (0.24 mg/dl) higher in the PA compared with the SA group (p = .028). Compared with a health education intervention, a 1-yr PA intervention results in a modest increase in systemic concentration of UA in older adults at risk for mobility disability

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalJournal of Aging and Physical Activity
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Aging
  • Exercise
  • Health education

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Gerontology
  • Geriatrics and Gerontology

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