Abstract
Objective: To determine whether drug treatment of Schistosomiasis mansoni infection leads to a reduction in plasma HIV-1 RNA concentration in coinfected individuals. Methods: Stool and plasma samples were obtained prospectively from a cohort of HIV-infected persons (n30) in Kisumu, Kenya, before and after treatment of schistosomiasis with praziquantel (mean follow-up, 5.6 months; range 1-15 months). Schistosomal circulating cathodic antigen (CCA) concentrations in plasma were determined by ELISA and fecal egg counts were determined by microscopy. HIV-1 RNA concentrations were measured in pre- and post-treatment plasma samples obtained from the patients whose stool samples remained free of schistosomal eggs for the great majority of the follow-up period. Results: Comparison of pretreatment and follow-up samples revealed that mean ± SD fecal egg burden was reduced by 96.7% (481.5 ± 803.5 versus 16.1 ± 24.4 eggs/g feces) and mean plasma CCA concentration decreased by 90.1% (3.22 ± 3.26 versus 0.32 ± 0.38 μg/ml). In contrast, mean plasma HIV-1 load increased from 3.60 ± 0.90 to 3.93 ± 0.95 log10 RNA copies/ml (P< 0.001). Although no correlation was found between changes in HIV-1 load and changes in schistosomal burden, there was a significant correlation between changes in plasma HIV load and the time interval between pretreatment and follow-up samples (r = 0.41; P = 0.027). Conclusions: Treatment of schistosomiasis was not associated with a reduction in plasma HIV-1 load. This study does not, however, exclude the possibility of an adverse effect of helminthic infections on HIV-1 pathogenesis. (C) 2000 Lippincott Williams and Wilkins.
Original language | English (US) |
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Pages (from-to) | 2437-2443 |
Number of pages | 7 |
Journal | AIDS |
Volume | 14 |
Issue number | 16 |
DOIs | |
State | Published - 2000 |
Keywords
- Africa
- Coinfections
- HIV-1
- Immune activation
- Plasma HIV load
- Praziquantel
- Schistosomiasis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases