The effect of treatment of schistosomiasis on blood plasma HIV-1 RNA concentration in coinfected individuals

Stephen D. Lawn, Diana M.S. Karanja, Pauline Mwinzi, Julius Andove, Daniel G. Colley, Thomas M. Folks, W. Evan Secor

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    73 Scopus citations

    Abstract

    Objective: To determine whether drug treatment of Schistosomiasis mansoni infection leads to a reduction in plasma HIV-1 RNA concentration in coinfected individuals. Methods: Stool and plasma samples were obtained prospectively from a cohort of HIV-infected persons (n30) in Kisumu, Kenya, before and after treatment of schistosomiasis with praziquantel (mean follow-up, 5.6 months; range 1-15 months). Schistosomal circulating cathodic antigen (CCA) concentrations in plasma were determined by ELISA and fecal egg counts were determined by microscopy. HIV-1 RNA concentrations were measured in pre- and post-treatment plasma samples obtained from the patients whose stool samples remained free of schistosomal eggs for the great majority of the follow-up period. Results: Comparison of pretreatment and follow-up samples revealed that mean ± SD fecal egg burden was reduced by 96.7% (481.5 ± 803.5 versus 16.1 ± 24.4 eggs/g feces) and mean plasma CCA concentration decreased by 90.1% (3.22 ± 3.26 versus 0.32 ± 0.38 μg/ml). In contrast, mean plasma HIV-1 load increased from 3.60 ± 0.90 to 3.93 ± 0.95 log10 RNA copies/ml (P< 0.001). Although no correlation was found between changes in HIV-1 load and changes in schistosomal burden, there was a significant correlation between changes in plasma HIV load and the time interval between pretreatment and follow-up samples (r = 0.41; P = 0.027). Conclusions: Treatment of schistosomiasis was not associated with a reduction in plasma HIV-1 load. This study does not, however, exclude the possibility of an adverse effect of helminthic infections on HIV-1 pathogenesis. (C) 2000 Lippincott Williams and Wilkins.

    Original languageEnglish (US)
    Pages (from-to)2437-2443
    Number of pages7
    JournalAIDS
    Volume14
    Issue number16
    DOIs
    StatePublished - Nov 27 2000

    Keywords

    • Africa
    • Coinfections
    • HIV-1
    • Immune activation
    • Plasma HIV load
    • Praziquantel
    • Schistosomiasis

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Infectious Diseases

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  • Cite this

    Lawn, S. D., Karanja, D. M. S., Mwinzi, P., Andove, J., Colley, D. G., Folks, T. M., & Secor, W. E. (2000). The effect of treatment of schistosomiasis on blood plasma HIV-1 RNA concentration in coinfected individuals. AIDS, 14(16), 2437-2443. https://doi.org/10.1097/00002030-200011100-00004