The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in compliance with trabecular cutting

David L. Halaney; Arnav Sanyal; Navid A. Nafissi; Daniel Escobedo; Martin Goros; Joel Michalek; Pedro J. Acevedo; William Perez; G. Patricia Escobar; Marc D. Feldman; Hai Chao Han

doi:10.1115/1.4035585

The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in compliance with trabecular cutting

David L. Halaney, Arnav Sanyal, Navid A. Nafissi, Daniel Escobedo, Martin Goros, Joel Michalek, Pedro J. Acevedo, William Perez, G. Patricia Escobar, Marc D. Feldman, Hai Chao Han

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p<0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.

Original language	English (US)
Article number	031012
Journal	Journal of Biomechanical Engineering
Volume	139
Issue number	3
DOIs	https://doi.org/10.1115/1.4035585
State	Published - Mar 1 2017

Keywords

Hypertrophy
LV compliance
Stiffness
Surgery
Trabeculae Carneae
Wall stress

ASJC Scopus subject areas

Physiology (medical)
Biomedical Engineering

Access to Document

10.1115/1.4035585

Cite this

Halaney, D. L., Sanyal, A., Nafissi, N. A., Escobedo, D., Goros, M., Michalek, J., Acevedo, P. J., Perez, W., Escobar, G. P., Feldman, M. D., & Han, H. C. (2017). The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in compliance with trabecular cutting. Journal of Biomechanical Engineering, 139(3), Article 031012. https://doi.org/10.1115/1.4035585

@article{8de51ab1ad4741c797bfdfc522fec3ba,

title = "The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in compliance with trabecular cutting",

abstract = "The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p<0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.",

keywords = "Hypertrophy, LV compliance, Stiffness, Surgery, Trabeculae Carneae, Wall stress",

author = "Halaney, {David L.} and Arnav Sanyal and Nafissi, {Navid A.} and Daniel Escobedo and Martin Goros and Joel Michalek and Acevedo, {Pedro J.} and William Perez and Escobar, {G. Patricia} and Feldman, {Marc D.} and Han, {Hai Chao}",

note = "Publisher Copyright: {\textcopyright} 2017 by ASME.",

year = "2017",

month = mar,

day = "1",

doi = "10.1115/1.4035585",

language = "English (US)",

volume = "139",

journal = "Journal of Biomechanical Engineering",

issn = "0148-0731",

publisher = "American Society of Mechanical Engineers(ASME)",

number = "3",

}

TY - JOUR

T1 - The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance

T2 - Improvement in compliance with trabecular cutting

AU - Halaney, David L.

AU - Sanyal, Arnav

AU - Nafissi, Navid A.

AU - Escobedo, Daniel

AU - Goros, Martin

AU - Michalek, Joel

AU - Acevedo, Pedro J.

AU - Perez, William

AU - Escobar, G. Patricia

AU - Feldman, Marc D.

AU - Han, Hai Chao

PY - 2017/3/1

Y1 - 2017/3/1

N2 - The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p<0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.

AB - The role of trabeculae carneae in modulating left ventricular (LV) diastolic compliance remains unclear. The objective of this study was to determine the contribution of trabeculae carneae to the LV diastolic compliance. LV pressure-volume compliance curves were measured in six human heart explants from patients with LV hypertrophy at baseline and following trabecular cutting. The effect of trabecular cutting was also analyzed with finite-element model (FEM) simulations. Our results demonstrated that LV compliance improved after trabecular cutting (p<0.001). Finite-element simulations further demonstrated that stiffer trabeculae reduce LV compliance further, and that the presence of trabeculae reduced the wall stress in the apex. In conclusion, we demonstrate that integrity of the LV and trabeculae is important to maintain LV stiffness and loss in trabeculae leads to more LV compliance.

KW - Hypertrophy

KW - LV compliance

KW - Stiffness

KW - Surgery

KW - Trabeculae Carneae

KW - Wall stress

UR - http://www.scopus.com/inward/record.url?scp=85010442978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85010442978&partnerID=8YFLogxK

U2 - 10.1115/1.4035585

DO - 10.1115/1.4035585

M3 - Article

C2 - 28024161

AN - SCOPUS:85010442978

SN - 0148-0731

VL - 139

JO - Journal of Biomechanical Engineering

JF - Journal of Biomechanical Engineering

IS - 3

M1 - 031012

ER -

The Effect of Trabeculae Carneae on Left Ventricular Diastolic Compliance: Improvement in compliance with trabecular cutting

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this