The effect of the fluorescent probe, 3,3′-dipropylthiodicarbocyanine iodide, on the membrane potential of Ehrlich ascites tumor cells

Thomas C. Smith, Susan C. Robinson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The effects of the potential-sensitive fluorescent dye, 3,3′dipropylthiodicarbocyanine iodide, on factors establishing the membrane potential of Ehrlich ascites tumor cells have been tested. The dye itself induces membrane hyperpolarization as monitored by electrophysiological methods. In addition, the dye inhibits active (Na++K+-transport and increases cell membrane permeability to K+ by about 65% in these cells.

Original languageEnglish (US)
Pages (from-to)722-727
Number of pages6
JournalTopics in Catalysis
Volume95
Issue number2
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Biophysics
  • Molecular Biology

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