The effect of testosterone and other adrenal steroids on PMS-induced ovulation in the immature rat

N. Hagino, J. W. Goldzieher

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

17α-hydroxyprogesterone (up to 200 μg/day) and 11β-hydroxyandrostenedione (up to 500 μg) had no effect on PMS-induced ovulation in intact immature rats. 10 μg/day of testosterone propionate (TP) on days 28–30 of life decreased the percent of animals ovulating and the number of ova produced; this effect persisted in adrenal-ectomized animals with or without corticosterone replacement. Three daily doses of 10 μg TP increased the electrical threshold of the medial preoplic area in pentobarbital-blocked, PMS-stimulated animals. and TP decreased the rate of release and synthesis of FSH during the ovulatory surge, and the storage and rate of release of LH ; it also inhibited the response to HCG in the PMS-primed animal, suggesting a direct target-organ effect.

Original languageEnglish (US)
Pages (from-to)27-39
Number of pages13
JournalNeuroendocrinology
Volume17
Issue number1
DOIs
StatePublished - 1975
Externally publishedYes

Keywords

  • 11β-Hydroxyandrostenedione
  • 17α-Hydroxyprogesterone
  • Ovulation
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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