The effect of synthetic corticosteroids on ovarian function in the baboon

Nobuyoshi Hagino

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Parenteral injection of triamcinolone at the time of menstruation or during the early stage of follicle development blocked ovulation and advanced the time of the following menstruation in baboons. The steroid was less effective if given during the immediate preovulatory phase. Injection of triamcinolone at the time of menses for 2-7 consecutive cycles consistently disrupted follicle development and ovulation. The menstrual cycles were shortened, but the actual cycle lengths were quite consistent and regular. Administration of 50 mg cortisol at the time of menstruation did not affect the following menstrual cycle and ovulation. It is inferred that a synthetic corticosteroid can exert important effects on the gonadotrophin regulatory mechanism in the baboon and that the contrast or similarity of the natural corticosteroid to synthetic corticosteroid bears further investigation.

Original languageEnglish (US)
Pages (from-to)716-721
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume35
Issue number5
DOIs
StatePublished - 1972
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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