The effect of seizures on recovery of function following cortical contusion in the rat

Dennis M. Feeney, Brigitte Y Bailey, Michael G. Boyeson, David A. Hovda, Richard L. Sutton

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The effect of seizures on recovery of motor function was studied in rats following unilateral contusion of the sensorimotor cotex. Animals receiving two electroconvulsive seizures (ECSs) within the first 24 hours postcontusion showed accelerated recovery of beam-walking ability, reduced volume of necrosis and less spontaneous activity compared to animals receiving only contusions. Animals receiving seven ECSs after contusion had an even smaller volume of necrosis and also reduced spontaneous activity compared to the two ECS group and to controls receiving contusions alone. However, for recovery of beam-walking ability, the seven ECS group did not differ from control rats receiving only contusions. The results are discussed in terms of the effects of seizures on catcholamines, gamma-amino butyric acid, cerebral blood flow and possible effects on remote functional depression after brain injury.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalBrain Injury
Volume1
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Recovery of Function
Contusions
Seizures
Walking
Cerebrovascular Circulation
Necrosis
Butyric Acid
Brain Injuries
Brain Contusion
Control Groups

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Feeney, D. M., Bailey, B. Y., Boyeson, M. G., Hovda, D. A., & Sutton, R. L. (1987). The effect of seizures on recovery of function following cortical contusion in the rat. Brain Injury, 1(1), 27-32. https://doi.org/10.3109/02699058709034441

The effect of seizures on recovery of function following cortical contusion in the rat. / Feeney, Dennis M.; Bailey, Brigitte Y; Boyeson, Michael G.; Hovda, David A.; Sutton, Richard L.

In: Brain Injury, Vol. 1, No. 1, 1987, p. 27-32.

Research output: Contribution to journalArticle

Feeney, DM, Bailey, BY, Boyeson, MG, Hovda, DA & Sutton, RL 1987, 'The effect of seizures on recovery of function following cortical contusion in the rat', Brain Injury, vol. 1, no. 1, pp. 27-32. https://doi.org/10.3109/02699058709034441
Feeney, Dennis M. ; Bailey, Brigitte Y ; Boyeson, Michael G. ; Hovda, David A. ; Sutton, Richard L. / The effect of seizures on recovery of function following cortical contusion in the rat. In: Brain Injury. 1987 ; Vol. 1, No. 1. pp. 27-32.
@article{ac8ae36891f54e2aa1e4bdd5097e2874,
title = "The effect of seizures on recovery of function following cortical contusion in the rat",
abstract = "The effect of seizures on recovery of motor function was studied in rats following unilateral contusion of the sensorimotor cotex. Animals receiving two electroconvulsive seizures (ECSs) within the first 24 hours postcontusion showed accelerated recovery of beam-walking ability, reduced volume of necrosis and less spontaneous activity compared to animals receiving only contusions. Animals receiving seven ECSs after contusion had an even smaller volume of necrosis and also reduced spontaneous activity compared to the two ECS group and to controls receiving contusions alone. However, for recovery of beam-walking ability, the seven ECS group did not differ from control rats receiving only contusions. The results are discussed in terms of the effects of seizures on catcholamines, gamma-amino butyric acid, cerebral blood flow and possible effects on remote functional depression after brain injury.",
author = "Feeney, {Dennis M.} and Bailey, {Brigitte Y} and Boyeson, {Michael G.} and Hovda, {David A.} and Sutton, {Richard L.}",
year = "1987",
doi = "10.3109/02699058709034441",
language = "English (US)",
volume = "1",
pages = "27--32",
journal = "Brain Injury",
issn = "0269-9052",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - The effect of seizures on recovery of function following cortical contusion in the rat

AU - Feeney, Dennis M.

AU - Bailey, Brigitte Y

AU - Boyeson, Michael G.

AU - Hovda, David A.

AU - Sutton, Richard L.

PY - 1987

Y1 - 1987

N2 - The effect of seizures on recovery of motor function was studied in rats following unilateral contusion of the sensorimotor cotex. Animals receiving two electroconvulsive seizures (ECSs) within the first 24 hours postcontusion showed accelerated recovery of beam-walking ability, reduced volume of necrosis and less spontaneous activity compared to animals receiving only contusions. Animals receiving seven ECSs after contusion had an even smaller volume of necrosis and also reduced spontaneous activity compared to the two ECS group and to controls receiving contusions alone. However, for recovery of beam-walking ability, the seven ECS group did not differ from control rats receiving only contusions. The results are discussed in terms of the effects of seizures on catcholamines, gamma-amino butyric acid, cerebral blood flow and possible effects on remote functional depression after brain injury.

AB - The effect of seizures on recovery of motor function was studied in rats following unilateral contusion of the sensorimotor cotex. Animals receiving two electroconvulsive seizures (ECSs) within the first 24 hours postcontusion showed accelerated recovery of beam-walking ability, reduced volume of necrosis and less spontaneous activity compared to animals receiving only contusions. Animals receiving seven ECSs after contusion had an even smaller volume of necrosis and also reduced spontaneous activity compared to the two ECS group and to controls receiving contusions alone. However, for recovery of beam-walking ability, the seven ECS group did not differ from control rats receiving only contusions. The results are discussed in terms of the effects of seizures on catcholamines, gamma-amino butyric acid, cerebral blood flow and possible effects on remote functional depression after brain injury.

UR - http://www.scopus.com/inward/record.url?scp=0011490044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0011490044&partnerID=8YFLogxK

U2 - 10.3109/02699058709034441

DO - 10.3109/02699058709034441

M3 - Article

C2 - 3454667

AN - SCOPUS:0011490044

VL - 1

SP - 27

EP - 32

JO - Brain Injury

JF - Brain Injury

SN - 0269-9052

IS - 1

ER -