The effect of resveratrol on neurodegenerative disorders: Possible protective actions against autophagy, apoptosis, inflammation and oxidative stress

Mohammad H. Pourhanifeh, Rana Shafabakhsh, Russel J. Reiter, Zatollah Asemi

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

The prevalence of neurodegenerative disorders characterized by the loss of neuronal function is rapidly increasing. The pathogenesis of the majority of these diseases is not entirely clear, but current evidence has shown the possibility that autophagy, apoptosis, inflammation and oxidative stress are involved. The present review summarizes the therapeutic effects of resveratrol on neurodegenerative disorders, based on the especially molecular biology of these diseases. The PubMed, Cochrane, Web of Science and Scopus databases were searched for studies published in English until March 30th, 2019 that contained data for the role of inflammation, oxidative stress, angiogenesis and apoptosis in the neurodegenerative disorders. There are also studies documenting the role of molecular processes in the progression of central nervous system diseases. Based on current evidence, resveratrol has potential properties that may reduce cell damage due to inflammation. This polyphenol affects cellular processes, including autophagy and the apoptosis cascade under stressful conditions. Current evidence supports the beneficial effects of resveratrol on the therapy of neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)2178-2191
Number of pages14
JournalCurrent pharmaceutical design
Volume25
Issue number19
DOIs
StatePublished - Jan 1 2019

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Keywords

  • Apoptosis
  • Autophagy
  • Inflammation
  • Oxidative stress
  • Parkinson’s disease
  • Resveratrol

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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