The Effect of Race/Ethnicity on the Accuracy of the 2001 Partin Tables for Predicting Pathologic Stage of Localized Prostate Cancer

Elisabeth I. Heath, Michael W. Kattan, Isaac J. Powell, Wael Sakr, Timothy C. Brand, Benjamin A. Rybicki, Ian M. Thompson, William J. Aronson, Martha K. Terris, Christopher J. Kane, Joseph C. Presti, Christopher L. Amling, Stephen J. Freedland

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Abstract

Objectives: To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States. Methods: We compiled a large multiethnic cohort of men (n = 3748) treated with radical prostatectomy at multiple sites, including all of the sites of the Department of Veterans Affairs-based Shared Equal Access Regional Cancer Hospital (SEARCH) database (n = 1524), Wayne State University (n = 1305), the University of Texas Health Science Center (n = 522), and the Henry Ford Hospital (n = 397). We evaluated the accuracy of the 2001 Partin Tables using area under the receiver operator characteristic curve (AUC) separately among African American and white men. Results: African American men (n = 1188, 32%), despite being more likely to have clinical Stage T1c disease (56% versus 47%, chi-square P <0.001), had higher preoperative PSA values (9.1 versus 7.7 ng/mL, rank-sum P <0.001) and were more likely to have higher-grade disease on diagnostic biopsy (chi-square P = 0.005). Despite these differences in baseline clinical characteristics, the 2001 Partin Tables performed equally well in both racial groups. Specifically, there were no differences in the AUC for African American and white men for predicting organ-confined disease (AUC 0.73 versus 0.72; P = 0.56), extraprostatic extension (AUC 0.62 versus 0.62; P = 0.99), or seminal vesicle invasion (AUC 0.77 versus 0.79; P = 0.53). Conclusions: These data lend further support to the idea that although baseline differences between the races existed that may underlie an overall more aggressive disease among African American men, for the individual patient, race is not valuable for prognostication.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalUrology
Volume71
Issue number1
DOIs
StatePublished - Jan 2008

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Nomograms
Prostatic Neoplasms
African Americans
Area Under Curve
Prostatectomy
Cancer Care Facilities
Seminal Vesicles
Veterans
Databases
Biopsy
Health

ASJC Scopus subject areas

  • Urology

Cite this

Heath, E. I., Kattan, M. W., Powell, I. J., Sakr, W., Brand, T. C., Rybicki, B. A., ... Freedland, S. J. (2008). The Effect of Race/Ethnicity on the Accuracy of the 2001 Partin Tables for Predicting Pathologic Stage of Localized Prostate Cancer. Urology, 71(1), 151-155. https://doi.org/10.1016/j.urology.2007.08.016

The Effect of Race/Ethnicity on the Accuracy of the 2001 Partin Tables for Predicting Pathologic Stage of Localized Prostate Cancer. / Heath, Elisabeth I.; Kattan, Michael W.; Powell, Isaac J.; Sakr, Wael; Brand, Timothy C.; Rybicki, Benjamin A.; Thompson, Ian M.; Aronson, William J.; Terris, Martha K.; Kane, Christopher J.; Presti, Joseph C.; Amling, Christopher L.; Freedland, Stephen J.

In: Urology, Vol. 71, No. 1, 01.2008, p. 151-155.

Research output: Contribution to journalArticle

Heath, EI, Kattan, MW, Powell, IJ, Sakr, W, Brand, TC, Rybicki, BA, Thompson, IM, Aronson, WJ, Terris, MK, Kane, CJ, Presti, JC, Amling, CL & Freedland, SJ 2008, 'The Effect of Race/Ethnicity on the Accuracy of the 2001 Partin Tables for Predicting Pathologic Stage of Localized Prostate Cancer', Urology, vol. 71, no. 1, pp. 151-155. https://doi.org/10.1016/j.urology.2007.08.016
Heath, Elisabeth I. ; Kattan, Michael W. ; Powell, Isaac J. ; Sakr, Wael ; Brand, Timothy C. ; Rybicki, Benjamin A. ; Thompson, Ian M. ; Aronson, William J. ; Terris, Martha K. ; Kane, Christopher J. ; Presti, Joseph C. ; Amling, Christopher L. ; Freedland, Stephen J. / The Effect of Race/Ethnicity on the Accuracy of the 2001 Partin Tables for Predicting Pathologic Stage of Localized Prostate Cancer. In: Urology. 2008 ; Vol. 71, No. 1. pp. 151-155.
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abstract = "Objectives: To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States. Methods: We compiled a large multiethnic cohort of men (n = 3748) treated with radical prostatectomy at multiple sites, including all of the sites of the Department of Veterans Affairs-based Shared Equal Access Regional Cancer Hospital (SEARCH) database (n = 1524), Wayne State University (n = 1305), the University of Texas Health Science Center (n = 522), and the Henry Ford Hospital (n = 397). We evaluated the accuracy of the 2001 Partin Tables using area under the receiver operator characteristic curve (AUC) separately among African American and white men. Results: African American men (n = 1188, 32{\%}), despite being more likely to have clinical Stage T1c disease (56{\%} versus 47{\%}, chi-square P <0.001), had higher preoperative PSA values (9.1 versus 7.7 ng/mL, rank-sum P <0.001) and were more likely to have higher-grade disease on diagnostic biopsy (chi-square P = 0.005). Despite these differences in baseline clinical characteristics, the 2001 Partin Tables performed equally well in both racial groups. Specifically, there were no differences in the AUC for African American and white men for predicting organ-confined disease (AUC 0.73 versus 0.72; P = 0.56), extraprostatic extension (AUC 0.62 versus 0.62; P = 0.99), or seminal vesicle invasion (AUC 0.77 versus 0.79; P = 0.53). Conclusions: These data lend further support to the idea that although baseline differences between the races existed that may underlie an overall more aggressive disease among African American men, for the individual patient, race is not valuable for prognostication.",
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T1 - The Effect of Race/Ethnicity on the Accuracy of the 2001 Partin Tables for Predicting Pathologic Stage of Localized Prostate Cancer

AU - Heath, Elisabeth I.

AU - Kattan, Michael W.

AU - Powell, Isaac J.

AU - Sakr, Wael

AU - Brand, Timothy C.

AU - Rybicki, Benjamin A.

AU - Thompson, Ian M.

AU - Aronson, William J.

AU - Terris, Martha K.

AU - Kane, Christopher J.

AU - Presti, Joseph C.

AU - Amling, Christopher L.

AU - Freedland, Stephen J.

PY - 2008/1

Y1 - 2008/1

N2 - Objectives: To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States. Methods: We compiled a large multiethnic cohort of men (n = 3748) treated with radical prostatectomy at multiple sites, including all of the sites of the Department of Veterans Affairs-based Shared Equal Access Regional Cancer Hospital (SEARCH) database (n = 1524), Wayne State University (n = 1305), the University of Texas Health Science Center (n = 522), and the Henry Ford Hospital (n = 397). We evaluated the accuracy of the 2001 Partin Tables using area under the receiver operator characteristic curve (AUC) separately among African American and white men. Results: African American men (n = 1188, 32%), despite being more likely to have clinical Stage T1c disease (56% versus 47%, chi-square P <0.001), had higher preoperative PSA values (9.1 versus 7.7 ng/mL, rank-sum P <0.001) and were more likely to have higher-grade disease on diagnostic biopsy (chi-square P = 0.005). Despite these differences in baseline clinical characteristics, the 2001 Partin Tables performed equally well in both racial groups. Specifically, there were no differences in the AUC for African American and white men for predicting organ-confined disease (AUC 0.73 versus 0.72; P = 0.56), extraprostatic extension (AUC 0.62 versus 0.62; P = 0.99), or seminal vesicle invasion (AUC 0.77 versus 0.79; P = 0.53). Conclusions: These data lend further support to the idea that although baseline differences between the races existed that may underlie an overall more aggressive disease among African American men, for the individual patient, race is not valuable for prognostication.

AB - Objectives: To test the accuracy of the 2001 Partin Tables in African American men who underwent radical prostatectomy at multiple centers throughout the United States. Methods: We compiled a large multiethnic cohort of men (n = 3748) treated with radical prostatectomy at multiple sites, including all of the sites of the Department of Veterans Affairs-based Shared Equal Access Regional Cancer Hospital (SEARCH) database (n = 1524), Wayne State University (n = 1305), the University of Texas Health Science Center (n = 522), and the Henry Ford Hospital (n = 397). We evaluated the accuracy of the 2001 Partin Tables using area under the receiver operator characteristic curve (AUC) separately among African American and white men. Results: African American men (n = 1188, 32%), despite being more likely to have clinical Stage T1c disease (56% versus 47%, chi-square P <0.001), had higher preoperative PSA values (9.1 versus 7.7 ng/mL, rank-sum P <0.001) and were more likely to have higher-grade disease on diagnostic biopsy (chi-square P = 0.005). Despite these differences in baseline clinical characteristics, the 2001 Partin Tables performed equally well in both racial groups. Specifically, there were no differences in the AUC for African American and white men for predicting organ-confined disease (AUC 0.73 versus 0.72; P = 0.56), extraprostatic extension (AUC 0.62 versus 0.62; P = 0.99), or seminal vesicle invasion (AUC 0.77 versus 0.79; P = 0.53). Conclusions: These data lend further support to the idea that although baseline differences between the races existed that may underlie an overall more aggressive disease among African American men, for the individual patient, race is not valuable for prognostication.

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