The effect of pedigree complexity on quantitative trait linkage analysis

T. D. Dyer, J. Blangero, J. T. Williams, H. H H Göring, M. C. Mahaney

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Due to the computational difficulties of performing linkage analysis on large complex pedigrees, most investigators resort to simplifying such pedigrees by some ad hoc strategy. In this paper, we suggest an analytical method to compare the power of various pedigree simplification schemes by using the asymptotic distribution of the likelihood-ratio statistic. We applied the method to the large Hutterite pedigree. Our results indicate that the breaking and reduction of inbreeding loops can greatly diminish the power to localize quantitative trait loci. We also present an efficient Monte Carlo method for estimating identity-by-descent allele sharing in large complex pedigrees. This method is used to facilitate a linkage analysis of serum IgE levels in the Hutterites without simplifying the pedigree.

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
StatePublished - 2001
Externally publishedYes

Fingerprint

Pedigree
Monte Carlo Method
Inbreeding
Quantitative Trait Loci
Immunoglobulin E
Alleles
Research Personnel
Serum

Keywords

  • Expected LOD score
  • Inbred pedigree
  • Power
  • Statistical genetics
  • Variance components

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Dyer, T. D., Blangero, J., Williams, J. T., Göring, H. H. H., & Mahaney, M. C. (2001). The effect of pedigree complexity on quantitative trait linkage analysis. Genetic Epidemiology, 21(SUPPL. 1).

The effect of pedigree complexity on quantitative trait linkage analysis. / Dyer, T. D.; Blangero, J.; Williams, J. T.; Göring, H. H H; Mahaney, M. C.

In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

Dyer, TD, Blangero, J, Williams, JT, Göring, HHH & Mahaney, MC 2001, 'The effect of pedigree complexity on quantitative trait linkage analysis', Genetic Epidemiology, vol. 21, no. SUPPL. 1.
Dyer TD, Blangero J, Williams JT, Göring HHH, Mahaney MC. The effect of pedigree complexity on quantitative trait linkage analysis. Genetic Epidemiology. 2001;21(SUPPL. 1).
Dyer, T. D. ; Blangero, J. ; Williams, J. T. ; Göring, H. H H ; Mahaney, M. C. / The effect of pedigree complexity on quantitative trait linkage analysis. In: Genetic Epidemiology. 2001 ; Vol. 21, No. SUPPL. 1.
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