The effect of patient factors on response outcomes to Botox treatment of spasmodic dysphonia

Donna S. Lundy, F. Ling Lu, Roy R. Casiano, Jun W. Xue

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Injection of botulinum toxin (Botox) into the laryngeal muscles has become the treatment of choice for controlling the symptoms of spasmodic dysphonia (SD). Currently, no specific battery of objective tests to assess the outcome is universally accepted. The purpose of this study was to investigate demographic, clinical, and treatment factors with voice outcome following Botox injection. Sixty-eight patients with adductor SD who underwent at least one Botox injection during a 5-year period were studied. Voice outcome measures were made from patient self-reporting scales and included overall vocal quality, length of response, and duration of breathiness. Vocal quality was significantly correlated with the underlying severity of vocal symptoms prior to treatment, incidence of breathiness and unilateral versus bilateral injection. The length of response was greater in males and following bilateral injections. An increased period of breathiness significantly correlated with bilateral injections.

Original languageEnglish (US)
Pages (from-to)460-466
Number of pages7
JournalJournal of Voice
Issue number4
StatePublished - 1998
Externally publishedYes


  • Botulinum toxin
  • Spasmodic dysphonia

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing
  • LPN and LVN


Dive into the research topics of 'The effect of patient factors on response outcomes to Botox treatment of spasmodic dysphonia'. Together they form a unique fingerprint.

Cite this