The effect of Maimendongtang on airway clearance and secretion

Shusheng Tai, Hirofumi Kai, Yoichiro Isohama, Hiroshi Moriuchi, Nobuyoshi Hagino, Takeshi Miyata

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

We investigated the effect of Maimendongtang on airway clearance and secretion in anaesthetized quails. The oral application of 1 g/kg of Maimendongtang significantly increased tracheal mucociliary transport velocity (MCTV), whereas 100 or 300 mg/kg of Maimendongtang failed to do so. Moreover, 300 mg/kg or 1 g/kg of Maimendongtang markedly attenuated human neutrophil elastase (HNE) or DNA-induced decrease in MCTV although 100 mg/kg of Maimendongtang had little effect. Furthermore, we found that Maimendongtang significantly restored HNE-induced increases in DNA, fucose and protein contents of airway surface fluid (ASF), whereas only Maimendontang itself significantly decreased the protein content. These results indicate that Maimendongtang increases MCTV and the increase may be, at least in part, ascribed to the amelioration of ASF in the trachea.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalPhytotherapy Research
Volume13
Issue number2
DOIs
StatePublished - Mar 1999
Externally publishedYes

Keywords

  • Airway surface fluid (ASF)
  • Deoxyribonucleic acid (DNA)
  • Human neutrophil elastase (HNE)
  • Maimendongtang
  • Mucociliary transport velocity (MCTV)
  • Quail

ASJC Scopus subject areas

  • Pharmacology

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