TY - JOUR
T1 - The effect of Maimendongtang on airway clearance and secretion
AU - Tai, Shusheng
AU - Kai, Hirofumi
AU - Isohama, Yoichiro
AU - Moriuchi, Hiroshi
AU - Hagino, Nobuyoshi
AU - Miyata, Takeshi
PY - 1999/3
Y1 - 1999/3
N2 - We investigated the effect of Maimendongtang on airway clearance and secretion in anaesthetized quails. The oral application of 1 g/kg of Maimendongtang significantly increased tracheal mucociliary transport velocity (MCTV), whereas 100 or 300 mg/kg of Maimendongtang failed to do so. Moreover, 300 mg/kg or 1 g/kg of Maimendongtang markedly attenuated human neutrophil elastase (HNE) or DNA-induced decrease in MCTV although 100 mg/kg of Maimendongtang had little effect. Furthermore, we found that Maimendongtang significantly restored HNE-induced increases in DNA, fucose and protein contents of airway surface fluid (ASF), whereas only Maimendontang itself significantly decreased the protein content. These results indicate that Maimendongtang increases MCTV and the increase may be, at least in part, ascribed to the amelioration of ASF in the trachea.
AB - We investigated the effect of Maimendongtang on airway clearance and secretion in anaesthetized quails. The oral application of 1 g/kg of Maimendongtang significantly increased tracheal mucociliary transport velocity (MCTV), whereas 100 or 300 mg/kg of Maimendongtang failed to do so. Moreover, 300 mg/kg or 1 g/kg of Maimendongtang markedly attenuated human neutrophil elastase (HNE) or DNA-induced decrease in MCTV although 100 mg/kg of Maimendongtang had little effect. Furthermore, we found that Maimendongtang significantly restored HNE-induced increases in DNA, fucose and protein contents of airway surface fluid (ASF), whereas only Maimendontang itself significantly decreased the protein content. These results indicate that Maimendongtang increases MCTV and the increase may be, at least in part, ascribed to the amelioration of ASF in the trachea.
KW - Airway surface fluid (ASF)
KW - Deoxyribonucleic acid (DNA)
KW - Human neutrophil elastase (HNE)
KW - Maimendongtang
KW - Mucociliary transport velocity (MCTV)
KW - Quail
UR - http://www.scopus.com/inward/record.url?scp=0032992428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032992428&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1099-1573(199903)13:2<124::AID-PTR400>3.0.CO;2-F
DO - 10.1002/(SICI)1099-1573(199903)13:2<124::AID-PTR400>3.0.CO;2-F
M3 - Article
C2 - 10190186
AN - SCOPUS:0032992428
VL - 13
SP - 124
EP - 127
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 2
ER -