The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs

Kathie M. Dalessandri; Bo M.T. Lantz; Julio C. Palmaz

doi:10.1007/BF02577065

The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs

Kathie M. Dalessandri, Bo M.T. Lantz, Julio C. Palmaz

Department of Radiology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympa-thectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0%±2.3 and 6.0%±2.9 respectively n=13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizote (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decrease significantly after sympathectomy (p<0.05).

Original language	English (US)
Pages (from-to)	82-85
Number of pages	4
Journal	Cardiovascular and Interventional Radiology
Volume	11
Issue number	2
DOIs	https://doi.org/10.1007/BF02577065
State	Published - Mar 1988

Keywords

Postsynaptic vasoactive response
Sympathectomy
Tolazoline hydrochloride
Video dilution technique

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Radiology Nuclear Medicine and imaging

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10.1007/BF02577065

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title = "The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs",

abstract = "The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympa-thectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0%±2.3 and 6.0%±2.9 respectively n=13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizote (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decrease significantly after sympathectomy (p<0.05).",

keywords = "Postsynaptic vasoactive response, Sympathectomy, Tolazoline hydrochloride, Video dilution technique",

author = "Dalessandri, {Kathie M.} and Lantz, {Bo M.T.} and Palmaz, {Julio C.}",

year = "1988",

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doi = "10.1007/BF02577065",

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T1 - The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs

AU - Dalessandri, Kathie M.

AU - Lantz, Bo M.T.

AU - Palmaz, Julio C.

PY - 1988/3

Y1 - 1988/3

N2 - The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympa-thectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0%±2.3 and 6.0%±2.9 respectively n=13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizote (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decrease significantly after sympathectomy (p<0.05).

AB - The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympa-thectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0%±2.3 and 6.0%±2.9 respectively n=13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizote (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decrease significantly after sympathectomy (p<0.05).

KW - Postsynaptic vasoactive response

KW - Sympathectomy

KW - Tolazoline hydrochloride

KW - Video dilution technique

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The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs

Abstract

Keywords

ASJC Scopus subject areas

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