The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs

Kathie M. Dalessandri, Bo M T Lantz, Julio C Palmaz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympa-thectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0%±2.3 and 6.0%±2.9 respectively n=13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizote (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decrease significantly after sympathectomy (p<0.05).

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalCardioVascular and Interventional Radiology
Volume11
Issue number2
DOIs
StatePublished - Mar 1988
Externally publishedYes

Fingerprint

Sympathectomy
Vascular Smooth Muscle
Lower Extremity
Dogs
Tolazoline
Femoral Artery
Diatrizoate Meglumine
Meglumine
Diatrizoate
Indicator Dilution Techniques
Hyperemia
Vasodilator Agents
Cardiac Output
Sodium

Keywords

  • Postsynaptic vasoactive response
  • Sympathectomy
  • Tolazoline hydrochloride
  • Video dilution technique

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs. / Dalessandri, Kathie M.; Lantz, Bo M T; Palmaz, Julio C.

In: CardioVascular and Interventional Radiology, Vol. 11, No. 2, 03.1988, p. 82-85.

Research output: Contribution to journalArticle

Dalessandri, Kathie M. ; Lantz, Bo M T ; Palmaz, Julio C. / The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs. In: CardioVascular and Interventional Radiology. 1988 ; Vol. 11, No. 2. pp. 82-85.
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