The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympa-thectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0%±2.3 and 6.0%±2.9 respectively n=13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizote (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decrease significantly after sympathectomy (p<0.05).
- Postsynaptic vasoactive response
- Tolazoline hydrochloride
- Video dilution technique
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine