The effect of lumbar sympathectomy on postsynaptic vascular smooth muscle response in the lower limb in dogs

Kathie M. Dalessandri, Bo M.T. Lantz, Julio C. Palmaz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The intent of this experiment was to study the postsynaptic vasoactive response to tolazoline hydrochloride and sodium-meglumine diatrizoate (Renografin-76) after a unilateral lumbar sympa-thectomy in a dog model. Both lower extremities were examined using the video dilution technique before and 1-2 weeks after unilateral lumbar sympathectomy (SE). Results showed (1) resting blood flow in the femoral artery as a percentage of cardiac output did not change after sympathectomy (mean and SD before and after SE: 7.0%±2.3 and 6.0%±2.9 respectively n=13); (2) the reactive hyperemia in the femoral artery caused by sodium-meglumine diatrizote (Renografin-76) was unchanged after sympathectomy; (3) the vasodilator effect of tolazoline hydrochloride decrease significantly after sympathectomy (p<0.05).

Original languageEnglish (US)
Pages (from-to)82-85
Number of pages4
JournalCardiovascular and Interventional Radiology
Volume11
Issue number2
DOIs
StatePublished - Mar 1 1988

Keywords

  • Postsynaptic vasoactive response
  • Sympathectomy
  • Tolazoline hydrochloride
  • Video dilution technique

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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