The effect of long-term imipramine treatment on carbon dioxide-induced anxiety in panic disorder patients

S. W. Woods, D. S. Charney, P. L. Delgado, G. R. Heninger

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The authors examined whether long-term treatment with imipramine would decrease CO2-induced anxiety in 10 patients with panic disorder. The patients underwent CO2 testing after single-blind placebo testing and again after imipramine treatment. Scores on self-rated visual analog mood scales and panic attack symptom scales showed that the anxiogenic effects of CO2 were significantly reduced during long-term imipramine treatment. These results suggest that the mechanisms underlying CO2-induced anxiety may be similar to those involved in the pathophysiology of panic disorder.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalJournal of Clinical Psychiatry
Volume51
Issue number12
StatePublished - 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health

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