The Effect of Hypothermia on Experimentally Induced Hemorrhagic Pancreatic Necrosis

Pancreatic secretion in the dog following pilocarpine stimulation was markedly reduced by pancreatic hypothermia (15° to 23° C.) The mortality rate for pancreatic necrosis evoked by injection of bile salts or duodenal juice into the pancreatic duct, or by the Shwartzman reaction, was enhanced slightly by use of systemic (25° to 30° C.) or local (15° to 23° C.) hypothermia. Permeability of the cat esophagus to perfused human bile enriched with ox bile salts was not significantly altered by hypothermia (18° to 20° C).