The effect of feto-maternal blood type incompatibility on development of gestational diabetes mellitus

M. Kanat, S. B. Goksugur, T. Ozlu, A. Tunckale, B. Ozturk, F. Y. Ozturk, Y. Altuntas, Y. Suleymanoglu, H. Atmaca, N. Yolcu, I. Gonenc, T. Delibasi, S. Zuhur, O. Dikbas, G. Aktas, Y. Karagoz, Muhammad A Abdul-ghani

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Abstract

Objective. To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM). Materials and Methods. A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. OGTT was performed between the 24-28 weeks of gestation, but participants who were at high risk for GDM were tested after the first prenatal visit. In the postpartum period, maternal and infant blood types were determined. Presence of GDM was evaluated in terms of matched and unmatched fetal and maternal ABO and Rh blood types separately. Results. GDM was detected in 235 participants. Unmatched ABO blood types between the mother-infant pairs were present in 44.7% (n=105) of GDM (+) and 35.8 % (n=95) of GDM (-) patients. Incompatible feto-maternal ABO blood type was positively correlated with development of GDM which was marginally significant. (p=0.045; R=1.2;95% CL; 1.004-1.48). However, Rh feto-maternal blood type incompatibility was not related with development of GDM. Conclusions. Feto-maternal ABO blood type incompatibility may be a weak risk factor for the development of GDM.

Original languageEnglish (US)
JournalClinica Terapeutica
Volume165
Issue number2
DOIs
StatePublished - 2014

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Gestational Diabetes
Mothers
Glucose Tolerance Test
Fetal Blood
Routine Diagnostic Tests
Postpartum Period
Pregnant Women
Pregnancy

Keywords

  • ABO blood type
  • Gestational diabetes mellitus
  • Rh blood type

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kanat, M., Goksugur, S. B., Ozlu, T., Tunckale, A., Ozturk, B., Ozturk, F. Y., ... Abdul-ghani, M. A. (2014). The effect of feto-maternal blood type incompatibility on development of gestational diabetes mellitus. Clinica Terapeutica, 165(2). https://doi.org/10.7471/CT.2014.1698

The effect of feto-maternal blood type incompatibility on development of gestational diabetes mellitus. / Kanat, M.; Goksugur, S. B.; Ozlu, T.; Tunckale, A.; Ozturk, B.; Ozturk, F. Y.; Altuntas, Y.; Suleymanoglu, Y.; Atmaca, H.; Yolcu, N.; Gonenc, I.; Delibasi, T.; Zuhur, S.; Dikbas, O.; Aktas, G.; Karagoz, Y.; Abdul-ghani, Muhammad A.

In: Clinica Terapeutica, Vol. 165, No. 2, 2014.

Research output: Contribution to journalArticle

Kanat, M, Goksugur, SB, Ozlu, T, Tunckale, A, Ozturk, B, Ozturk, FY, Altuntas, Y, Suleymanoglu, Y, Atmaca, H, Yolcu, N, Gonenc, I, Delibasi, T, Zuhur, S, Dikbas, O, Aktas, G, Karagoz, Y & Abdul-ghani, MA 2014, 'The effect of feto-maternal blood type incompatibility on development of gestational diabetes mellitus', Clinica Terapeutica, vol. 165, no. 2. https://doi.org/10.7471/CT.2014.1698
Kanat, M. ; Goksugur, S. B. ; Ozlu, T. ; Tunckale, A. ; Ozturk, B. ; Ozturk, F. Y. ; Altuntas, Y. ; Suleymanoglu, Y. ; Atmaca, H. ; Yolcu, N. ; Gonenc, I. ; Delibasi, T. ; Zuhur, S. ; Dikbas, O. ; Aktas, G. ; Karagoz, Y. ; Abdul-ghani, Muhammad A. / The effect of feto-maternal blood type incompatibility on development of gestational diabetes mellitus. In: Clinica Terapeutica. 2014 ; Vol. 165, No. 2.
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abstract = "Objective. To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM). Materials and Methods. A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. OGTT was performed between the 24-28 weeks of gestation, but participants who were at high risk for GDM were tested after the first prenatal visit. In the postpartum period, maternal and infant blood types were determined. Presence of GDM was evaluated in terms of matched and unmatched fetal and maternal ABO and Rh blood types separately. Results. GDM was detected in 235 participants. Unmatched ABO blood types between the mother-infant pairs were present in 44.7{\%} (n=105) of GDM (+) and 35.8 {\%} (n=95) of GDM (-) patients. Incompatible feto-maternal ABO blood type was positively correlated with development of GDM which was marginally significant. (p=0.045; R=1.2;95{\%} CL; 1.004-1.48). However, Rh feto-maternal blood type incompatibility was not related with development of GDM. Conclusions. Feto-maternal ABO blood type incompatibility may be a weak risk factor for the development of GDM.",
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AU - Goksugur, S. B.

AU - Ozlu, T.

AU - Tunckale, A.

AU - Ozturk, B.

AU - Ozturk, F. Y.

AU - Altuntas, Y.

AU - Suleymanoglu, Y.

AU - Atmaca, H.

AU - Yolcu, N.

AU - Gonenc, I.

AU - Delibasi, T.

AU - Zuhur, S.

AU - Dikbas, O.

AU - Aktas, G.

AU - Karagoz, Y.

AU - Abdul-ghani, Muhammad A

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N2 - Objective. To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM). Materials and Methods. A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. OGTT was performed between the 24-28 weeks of gestation, but participants who were at high risk for GDM were tested after the first prenatal visit. In the postpartum period, maternal and infant blood types were determined. Presence of GDM was evaluated in terms of matched and unmatched fetal and maternal ABO and Rh blood types separately. Results. GDM was detected in 235 participants. Unmatched ABO blood types between the mother-infant pairs were present in 44.7% (n=105) of GDM (+) and 35.8 % (n=95) of GDM (-) patients. Incompatible feto-maternal ABO blood type was positively correlated with development of GDM which was marginally significant. (p=0.045; R=1.2;95% CL; 1.004-1.48). However, Rh feto-maternal blood type incompatibility was not related with development of GDM. Conclusions. Feto-maternal ABO blood type incompatibility may be a weak risk factor for the development of GDM.

AB - Objective. To assess the relation between fetal and maternal blood type (ABO, Rh) incompatibility and development of gestational diabetes mellitus (GDM). Materials and Methods. A total of 500 pregnant women underwent diagnostic test for GDM by a 100-g oral glucose tolerance test (OGTT) after an 8 to 12-h overnight fast participated in this study. OGTT was performed between the 24-28 weeks of gestation, but participants who were at high risk for GDM were tested after the first prenatal visit. In the postpartum period, maternal and infant blood types were determined. Presence of GDM was evaluated in terms of matched and unmatched fetal and maternal ABO and Rh blood types separately. Results. GDM was detected in 235 participants. Unmatched ABO blood types between the mother-infant pairs were present in 44.7% (n=105) of GDM (+) and 35.8 % (n=95) of GDM (-) patients. Incompatible feto-maternal ABO blood type was positively correlated with development of GDM which was marginally significant. (p=0.045; R=1.2;95% CL; 1.004-1.48). However, Rh feto-maternal blood type incompatibility was not related with development of GDM. Conclusions. Feto-maternal ABO blood type incompatibility may be a weak risk factor for the development of GDM.

KW - ABO blood type

KW - Gestational diabetes mellitus

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