The effect of elevated levels of thromboxane on host response to tumor

J. Paul Waymack, Gabriel Fernandes, Jaya Venkatraman, Eliezer Flescher, Roger W. Yurt, Ray F. Guzman, Arthur D. Mason, Basil A. Pruitt

Research output: Contribution to journalArticlepeer-review

Abstract

Previous studies have demonstrated that human malignancies can synthesize large amounts of thromboxane. It has also been reported that thromboxane can significantly alter multiple components of physiologic and immunologic function. We investigated the effect of elevated levels of thromboxane on host response to tumor using multiple rat models, and the long acting thromboxane analogue U‐46619. Administration of the thromboxane analogue was not found to significantly alter the growth of primary tumors or peritoneal metastases. The analogue was found to significantly decrease mean survival time with a pulmonary metastases model. The thromboxane analogue failed to alter macrophage cytotoxicity, lymphocyte cytotoxicity, T lymphocyte subset numbers, or lymphocyte blastogenic response. Administration of the thromboxane analogue decreased the rate of lymphocyte metabolism of glucose and decreased lymphocyte intracellular adenosine deaminase activity. In conclusion, elevated thromboxane levels do not appear to alter primary tumor growth or host immune function, but do decrease resistance to pulmonary metastases.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalJournal of Surgical Oncology
Volume49
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • T subset numbers
  • adenosine deaminase
  • blastogenic response
  • glucose metabolism
  • lymphocytes, cytotoxicity
  • macrophage cytotoxicity
  • pulmonary metastases model

ASJC Scopus subject areas

  • Surgery
  • Oncology

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