The effect of different light intensities on pineal melatonin content

George C. Brainard, Bruce A. Richardson, Larry J. Petterborg, Russel J. Reiter

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

In Syrian hamsters, elevated night-time pineal melatonin levels are quickly reduced to low daytime levels by exposing the animals to light. The purpose of this study was to determine the lowest light intensity capable of causing a large reduction in night-time levels of pineal melatonin in the male hamster. During the dark phase of the light: dark cycle, groups of hamsters were exposed to one of 8 different intensities of white fluorescent light: 5380, 2798, 151, 20.44, 5.38, 1.08, 0.11 and 0.01 lux. For each light intensity, pineals were collected from 8 hamsters each at 2 min before and at 2, 8 and 32 min after the lights were turned on. Pineal melatonin content was determined by radioimmunoassay. Light intensities of 1.08 lux or greater depressed pineal melatonin content significantly (P < 0.001). Light intensities of 0.11 or 0.01 lux failed to depress pineal melatonin levels. Thus, the apparent threshold for the action of white fluorescent light on hamster pineal melatonin content lies between 1.08 and 0.11 lux.

Original languageEnglish (US)
Pages (from-to)75-81
Number of pages7
JournalBrain Research
Volume233
Issue number1
DOIs
StatePublished - Feb 4 1982

Keywords

  • circadian
  • light intensity
  • melatonin
  • nocturnal
  • pineal

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'The effect of different light intensities on pineal melatonin content'. Together they form a unique fingerprint.

Cite this