The effect of diet on autogenous immunity to mouse mammary tumor virus in C3H/Bi mice

N. K. Day, G. Fernandes, S. S. Witkin, E. S. Thomas, N. H. Sarkar, R. A. Good

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Antibody levels to mouse mammary tumor virus (MuMTV) in sera of C3H/Bi, C57BL/6 and AKR mice were assayed by an enzyme-linked immunosorbent assay (ELISA). It was found that antibody levels to MuMTV were highest in sera of C3H/Bi females which have a high incidence of breast cancer and low in male C3H/Bi and female C3H/Bi foster-nursed on C57BL/6 females. Sera of C57BL/6 and AKR mice showed very low or undetectable levels of antibody to MuMTV. Reduction of caloric intake sufficient to inhibit mammary tumor formation strikingly inhibited formation of antibody against MuMTV. The lowest levels of antibody were observed in sera of mice fed 10 cal/day of a defined diet. Significantly higher levels developed in the sera of mice fed 16 cal/day of the same defined diet. The highest antibody levels against MuMTV, however, were seen in sera of mice fed lab chow ad libitum but no correlation was evident between levels of antibody and tumor size. These studies indicate that dietary caloric restriction has a profound influence on the development of both mammary adenocarcinoma and antibody responses to MuMTV.

Original languageEnglish (US)
Pages (from-to)813-818
Number of pages6
JournalInternational Journal of Cancer
Volume26
Issue number6
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Mouse mammary tumor virus
Inbred C3H Mouse
Immunity
Diet
Serum
Antibodies
Inbred AKR Mouse
Inbred C57BL Mouse
Antibody Formation
Breast Neoplasms
Neoplasm Antibodies
Caloric Restriction
Energy Intake
Adenocarcinoma
Breast
Enzyme-Linked Immunosorbent Assay
Incidence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Day, N. K., Fernandes, G., Witkin, S. S., Thomas, E. S., Sarkar, N. H., & Good, R. A. (1980). The effect of diet on autogenous immunity to mouse mammary tumor virus in C3H/Bi mice. International Journal of Cancer, 26(6), 813-818. https://doi.org/10.1002/ijc.2910260616

The effect of diet on autogenous immunity to mouse mammary tumor virus in C3H/Bi mice. / Day, N. K.; Fernandes, G.; Witkin, S. S.; Thomas, E. S.; Sarkar, N. H.; Good, R. A.

In: International Journal of Cancer, Vol. 26, No. 6, 1980, p. 813-818.

Research output: Contribution to journalArticle

Day, NK, Fernandes, G, Witkin, SS, Thomas, ES, Sarkar, NH & Good, RA 1980, 'The effect of diet on autogenous immunity to mouse mammary tumor virus in C3H/Bi mice', International Journal of Cancer, vol. 26, no. 6, pp. 813-818. https://doi.org/10.1002/ijc.2910260616
Day, N. K. ; Fernandes, G. ; Witkin, S. S. ; Thomas, E. S. ; Sarkar, N. H. ; Good, R. A. / The effect of diet on autogenous immunity to mouse mammary tumor virus in C3H/Bi mice. In: International Journal of Cancer. 1980 ; Vol. 26, No. 6. pp. 813-818.
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