The effect of antidepressant drugs on regional cerebral glucose utilization in the rat

Joseph C. Gerber, Junichiro Choki, David J. Brunswick, Martin Reivich, Alan Frazer

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The 2-deoxyglucose (2-DG) technique is a potentially powerful method for assessing the effect of centrally acting drugs on local neuronal function in the brain. Since little is established on the effect of antidepressant drugs on local functional activity throughout the brain, we have employed this technique to study the effects of desmethylimipramine (DMI), a tricyclic antidepressant, and phenelzine, a monoamine oxidase inhibitor used clinically as an antidepressant, on local glucose utilization. The drugs were administered either as an acute dose, or repeatedely for 7 days, or chronically for 28 days. The local metabolic rate of glucose was determined in 30 regions of rat brain. Acute DMI increased glucose utilization in 11 regions whereas, in contrast,chronic DMI decreased glucose utilization in 7 regions of rat brain. Many of the areas affected are those of the telencephalon and diencephalon that receive prominent noradrenergic innervation. This is consistent with the notion that acute DMI treatment leads to enhanced and chronic DMI treatment leads to reduced noradrenergic functioning in the CNS. In contrast to these effects with DMI, phenelzine had little effect on glucose utilization either after acute of chronic dosing.

Original languageEnglish (US)
Pages (from-to)319-325
Number of pages7
JournalBrain Research
Volume269
Issue number2
DOIs
StatePublished - Jun 20 1983
Externally publishedYes

Keywords

  • 2-deoxyglucose technique
  • antidepressants
  • desmethylimipramine
  • local cerebral metabolism
  • phenelzine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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