The effect of age on the expression of interleukin-2

Mohammad A. Pahlavani; Arlan Richardson

doi:10.1016/0047-6374(96)01725-3

The effect of age on the expression of interleukin-2

Mohammad A. Pahlavani, Arlan Richardson

Barshop Institute

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Abstract

Interleukin-2 (IL-2) is a growth promoting cytokine that has received a great deal of attention over the past decade with respect to aging and cancer. It is produced primarily by helper T cells and regulates the growth and function of various cells that are involved in cellular and humoral immunity. The expression of IL-2 has been found to decrease with age in humans and rodents. The decline in IL-2 production has been shown to parallel the age-related decrease in immunologic function. Several studies indicate that treatment of lymphocytes from old subjects with exogenous IL-2 or infusion of IL-2 into old animals partially or completely restores some of the immune functions that decline with age. The age-related decline in IL-2 production has been shown to arise from a decline in IL-2 transcription, and a recent study suggests that the transcription factor NFAT (nuclear factor of activated T cells) may play a role in the decline in IL-2 transcription.

Original language	English (US)
Pages (from-to)	125-154
Number of pages	30
Journal	Mechanisms of Ageing and Development
Volume	89
Issue number	3
DOIs	https://doi.org/10.1016/0047-6374(96)01725-3
State	Published - Aug 29 1996

Keywords

Aging
Immune system
Interleukin-2
Transcription
Transcription factors

ASJC Scopus subject areas

Aging
Developmental Biology

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title = "The effect of age on the expression of interleukin-2",

abstract = "Interleukin-2 (IL-2) is a growth promoting cytokine that has received a great deal of attention over the past decade with respect to aging and cancer. It is produced primarily by helper T cells and regulates the growth and function of various cells that are involved in cellular and humoral immunity. The expression of IL-2 has been found to decrease with age in humans and rodents. The decline in IL-2 production has been shown to parallel the age-related decrease in immunologic function. Several studies indicate that treatment of lymphocytes from old subjects with exogenous IL-2 or infusion of IL-2 into old animals partially or completely restores some of the immune functions that decline with age. The age-related decline in IL-2 production has been shown to arise from a decline in IL-2 transcription, and a recent study suggests that the transcription factor NFAT (nuclear factor of activated T cells) may play a role in the decline in IL-2 transcription.",

keywords = "Aging, Immune system, Interleukin-2, Transcription, Transcription factors",

author = "Pahlavani, {Mohammad A.} and Arlan Richardson",

note = "Funding Information: We thank Dr. Susan A. Moore for her review of the manuscript and helpful suggestions and Ms. Melissa D. Harris for her dedicated secretarial assistance.T his work was supported in part by grants from the National Institute of Health (AGO1548 and AG00677) and a grant from the American Federation for Aging Research.",

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AU - Richardson, Arlan

N1 - Funding Information: We thank Dr. Susan A. Moore for her review of the manuscript and helpful suggestions and Ms. Melissa D. Harris for her dedicated secretarial assistance.T his work was supported in part by grants from the National Institute of Health (AGO1548 and AG00677) and a grant from the American Federation for Aging Research.

PY - 1996/8/29

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N2 - Interleukin-2 (IL-2) is a growth promoting cytokine that has received a great deal of attention over the past decade with respect to aging and cancer. It is produced primarily by helper T cells and regulates the growth and function of various cells that are involved in cellular and humoral immunity. The expression of IL-2 has been found to decrease with age in humans and rodents. The decline in IL-2 production has been shown to parallel the age-related decrease in immunologic function. Several studies indicate that treatment of lymphocytes from old subjects with exogenous IL-2 or infusion of IL-2 into old animals partially or completely restores some of the immune functions that decline with age. The age-related decline in IL-2 production has been shown to arise from a decline in IL-2 transcription, and a recent study suggests that the transcription factor NFAT (nuclear factor of activated T cells) may play a role in the decline in IL-2 transcription.

AB - Interleukin-2 (IL-2) is a growth promoting cytokine that has received a great deal of attention over the past decade with respect to aging and cancer. It is produced primarily by helper T cells and regulates the growth and function of various cells that are involved in cellular and humoral immunity. The expression of IL-2 has been found to decrease with age in humans and rodents. The decline in IL-2 production has been shown to parallel the age-related decrease in immunologic function. Several studies indicate that treatment of lymphocytes from old subjects with exogenous IL-2 or infusion of IL-2 into old animals partially or completely restores some of the immune functions that decline with age. The age-related decline in IL-2 production has been shown to arise from a decline in IL-2 transcription, and a recent study suggests that the transcription factor NFAT (nuclear factor of activated T cells) may play a role in the decline in IL-2 transcription.

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KW - Immune system

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KW - Transcription

KW - Transcription factors

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The effect of age on the expression of interleukin-2

Abstract

Keywords

ASJC Scopus subject areas

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