TY - JOUR
T1 - The effect of acute maternal hemorrhage on the release of catecholamines in the pregnant ewe and the fetus
AU - Artal, Raul
AU - Glatz, Theodore H.
AU - Lam, Robert
AU - Nathanielsz, Peter W.
AU - Hobel, Calvin J.
PY - 1979/11/15
Y1 - 1979/11/15
N2 - Five chronically instrumented pregnant ewes and their fetuses were studied to assess the effect of acute maternal hemorrhage. The hemorrhage was produced in two stages; during the first stage 15% of the total maternal blood volume was removed, and then in a second stage an additional 15% was removed. Biophysical and biochemical variables were monitored. Plasma dopamine, norepinephrine, and epinephrine were determined by a sensitive radioenzymatic assay. A significant rise in maternal and fetal catecholamines was observed following an estimated maternal blood volume depletion of 30%. During a 15-minute recovery period, the maternal catecholamine concentrations returned to normal, while the fetal concentrations remained elevated. These changes were accompanied by significant changes in maternal and fetal homeostasis. The significance of these findings is discussed.
AB - Five chronically instrumented pregnant ewes and their fetuses were studied to assess the effect of acute maternal hemorrhage. The hemorrhage was produced in two stages; during the first stage 15% of the total maternal blood volume was removed, and then in a second stage an additional 15% was removed. Biophysical and biochemical variables were monitored. Plasma dopamine, norepinephrine, and epinephrine were determined by a sensitive radioenzymatic assay. A significant rise in maternal and fetal catecholamines was observed following an estimated maternal blood volume depletion of 30%. During a 15-minute recovery period, the maternal catecholamine concentrations returned to normal, while the fetal concentrations remained elevated. These changes were accompanied by significant changes in maternal and fetal homeostasis. The significance of these findings is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0018702341&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018702341&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(79)90398-3
DO - 10.1016/0002-9378(79)90398-3
M3 - Article
C2 - 40436
AN - SCOPUS:0018702341
VL - 135
SP - 818
EP - 822
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6
ER -