The echinocandin micafungin: A review of the pharmacology, spectrum of activity, clinical efficacy and safety

Nathan P. Wiederhold, James S. Lewis

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Micafungin is a relatively broad-spectrum antifungal agent available for clinical use in the US and Japan. By inhibiting the production of β-1,3-glucan, an essential fungal cell wall component, micafungin has reduced toxicity to mammalian cells while maintaining potent antifungal activity against many pathogenic fungi including polyene- and azole-resistant isolates. Indeed, micafungin has been shown to be efficacious in the treatment of infections caused by Candida and Aspergillus species in clinical trials without the associated toxicities of amphotericin B formulations and drug interactions that occur with the azoles. In this review, the pharmacology, spectrum of activity, clinical efficacy and safety profile of micafungin are discussed.

Original languageEnglish (US)
Pages (from-to)1155-1166
Number of pages12
JournalExpert Opinion on Pharmacotherapy
Volume8
Issue number8
DOIs
StatePublished - Jun 1 2007

Keywords

  • Aspergillus
  • Candida
  • Echinocandin
  • Invasive aspergillosis
  • Invasive candidiasis
  • Micafungin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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