The dynamics of murine LINE-1 subfamily amplification

N. Carol Casavant, Stephen C. Hardies

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have examined the dynamics of replication of the mouse LINE-1 retrotransposon within a single large expanding LINE-1 family found in a particular population of Mus spretus. This family has reached thousands of copies per haploid genome within 0.1 to 0.2 Myr and accounts for most, if not all, LINE-1 replication since 0.4 Myr ago. The family shows only one split into two clades during this time. From these data we propose a model that links the evolution of LINE-1 to the dynamics of its migration among mouse populations. We hypothesize that selected LINE-1 elements, referred to as master sequences, each amplify a subfamily within a distinct mouse population before migrating into the global mouse population. When these master sequences come in contact with each other by migration, generally one continues to expand at the expense of the other. We further discuss potential tests of this model.

Original languageEnglish (US)
Pages (from-to)390-397
Number of pages8
JournalJournal of Molecular Biology
Volume241
Issue number3
DOIs
StatePublished - 1994

Fingerprint

Population
Long Interspersed Nucleotide Elements
Retroelements
Haploidy
Genome

Keywords

  • Gene flow
  • LINE-1 amplification
  • Mouse population genetics
  • Repetitive DNA
  • Transposons

ASJC Scopus subject areas

  • Virology

Cite this

The dynamics of murine LINE-1 subfamily amplification. / Casavant, N. Carol; Hardies, Stephen C.

In: Journal of Molecular Biology, Vol. 241, No. 3, 1994, p. 390-397.

Research output: Contribution to journalArticle

Casavant, N. Carol ; Hardies, Stephen C. / The dynamics of murine LINE-1 subfamily amplification. In: Journal of Molecular Biology. 1994 ; Vol. 241, No. 3. pp. 390-397.
@article{6b91e4d15722414dbe6922318b829da7,
title = "The dynamics of murine LINE-1 subfamily amplification",
abstract = "We have examined the dynamics of replication of the mouse LINE-1 retrotransposon within a single large expanding LINE-1 family found in a particular population of Mus spretus. This family has reached thousands of copies per haploid genome within 0.1 to 0.2 Myr and accounts for most, if not all, LINE-1 replication since 0.4 Myr ago. The family shows only one split into two clades during this time. From these data we propose a model that links the evolution of LINE-1 to the dynamics of its migration among mouse populations. We hypothesize that selected LINE-1 elements, referred to as master sequences, each amplify a subfamily within a distinct mouse population before migrating into the global mouse population. When these master sequences come in contact with each other by migration, generally one continues to expand at the expense of the other. We further discuss potential tests of this model.",
keywords = "Gene flow, LINE-1 amplification, Mouse population genetics, Repetitive DNA, Transposons",
author = "Casavant, {N. Carol} and Hardies, {Stephen C.}",
year = "1994",
doi = "10.1006/jmbi.1994.1515",
language = "English (US)",
volume = "241",
pages = "390--397",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - The dynamics of murine LINE-1 subfamily amplification

AU - Casavant, N. Carol

AU - Hardies, Stephen C.

PY - 1994

Y1 - 1994

N2 - We have examined the dynamics of replication of the mouse LINE-1 retrotransposon within a single large expanding LINE-1 family found in a particular population of Mus spretus. This family has reached thousands of copies per haploid genome within 0.1 to 0.2 Myr and accounts for most, if not all, LINE-1 replication since 0.4 Myr ago. The family shows only one split into two clades during this time. From these data we propose a model that links the evolution of LINE-1 to the dynamics of its migration among mouse populations. We hypothesize that selected LINE-1 elements, referred to as master sequences, each amplify a subfamily within a distinct mouse population before migrating into the global mouse population. When these master sequences come in contact with each other by migration, generally one continues to expand at the expense of the other. We further discuss potential tests of this model.

AB - We have examined the dynamics of replication of the mouse LINE-1 retrotransposon within a single large expanding LINE-1 family found in a particular population of Mus spretus. This family has reached thousands of copies per haploid genome within 0.1 to 0.2 Myr and accounts for most, if not all, LINE-1 replication since 0.4 Myr ago. The family shows only one split into two clades during this time. From these data we propose a model that links the evolution of LINE-1 to the dynamics of its migration among mouse populations. We hypothesize that selected LINE-1 elements, referred to as master sequences, each amplify a subfamily within a distinct mouse population before migrating into the global mouse population. When these master sequences come in contact with each other by migration, generally one continues to expand at the expense of the other. We further discuss potential tests of this model.

KW - Gene flow

KW - LINE-1 amplification

KW - Mouse population genetics

KW - Repetitive DNA

KW - Transposons

UR - http://www.scopus.com/inward/record.url?scp=0027980860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027980860&partnerID=8YFLogxK

U2 - 10.1006/jmbi.1994.1515

DO - 10.1006/jmbi.1994.1515

M3 - Article

C2 - 8064855

AN - SCOPUS:0027980860

VL - 241

SP - 390

EP - 397

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

SN - 0022-2836

IS - 3

ER -