Abstract
We have examined the dynamics of replication of the mouse LINE-1 retrotransposon within a single large expanding LINE-1 family found in a particular population of Mus spretus. This family has reached thousands of copies per haploid genome within 0.1 to 0.2 Myr and accounts for most, if not all, LINE-1 replication since 0.4 Myr ago. The family shows only one split into two clades during this time. From these data we propose a model that links the evolution of LINE-1 to the dynamics of its migration among mouse populations. We hypothesize that selected LINE-1 elements, referred to as master sequences, each amplify a subfamily within a distinct mouse population before migrating into the global mouse population. When these master sequences come in contact with each other by migration, generally one continues to expand at the expense of the other. We further discuss potential tests of this model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 390-397 |
| Number of pages | 8 |
| Journal | Journal of Molecular Biology |
| Volume | 241 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1994 |
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Keywords
- Gene flow
- LINE-1 amplification
- Mouse population genetics
- Repetitive DNA
- Transposons
ASJC Scopus subject areas
- Virology
Cite this
The dynamics of murine LINE-1 subfamily amplification. / Casavant, N. Carol; Hardies, Stephen C.
In: Journal of Molecular Biology, Vol. 241, No. 3, 1994, p. 390-397.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The dynamics of murine LINE-1 subfamily amplification
AU - Casavant, N. Carol
AU - Hardies, Stephen C.
PY - 1994
Y1 - 1994
N2 - We have examined the dynamics of replication of the mouse LINE-1 retrotransposon within a single large expanding LINE-1 family found in a particular population of Mus spretus. This family has reached thousands of copies per haploid genome within 0.1 to 0.2 Myr and accounts for most, if not all, LINE-1 replication since 0.4 Myr ago. The family shows only one split into two clades during this time. From these data we propose a model that links the evolution of LINE-1 to the dynamics of its migration among mouse populations. We hypothesize that selected LINE-1 elements, referred to as master sequences, each amplify a subfamily within a distinct mouse population before migrating into the global mouse population. When these master sequences come in contact with each other by migration, generally one continues to expand at the expense of the other. We further discuss potential tests of this model.
AB - We have examined the dynamics of replication of the mouse LINE-1 retrotransposon within a single large expanding LINE-1 family found in a particular population of Mus spretus. This family has reached thousands of copies per haploid genome within 0.1 to 0.2 Myr and accounts for most, if not all, LINE-1 replication since 0.4 Myr ago. The family shows only one split into two clades during this time. From these data we propose a model that links the evolution of LINE-1 to the dynamics of its migration among mouse populations. We hypothesize that selected LINE-1 elements, referred to as master sequences, each amplify a subfamily within a distinct mouse population before migrating into the global mouse population. When these master sequences come in contact with each other by migration, generally one continues to expand at the expense of the other. We further discuss potential tests of this model.
KW - Gene flow
KW - LINE-1 amplification
KW - Mouse population genetics
KW - Repetitive DNA
KW - Transposons
UR - http://www.scopus.com/inward/record.url?scp=0027980860&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027980860&partnerID=8YFLogxK
U2 - 10.1006/jmbi.1994.1515
DO - 10.1006/jmbi.1994.1515
M3 - Article
C2 - 8064855
AN - SCOPUS:0027980860
VL - 241
SP - 390
EP - 397
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
SN - 0022-2836
IS - 3
ER -