The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis

St. Jude Children's Research Hospital—Washington University Pediatric Cancer Genome Project

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile the epigenetic and transcriptional changes that occur during retinogenesis in mice and humans. Although some progenitor genes and cell cycle genes were epigenetically silenced during retinogenesis, the most dramatic change was derepression of cell-type-specific differentiation programs. We identified developmental-stage-specific super-enhancers and showed that most epigenetic changes are conserved in humans and mice. To determine how the epigenome changes during tumorigenesis and reprogramming, we performed integrated epigenetic analysis of murine and human retinoblastomas and induced pluripotent stem cells (iPSCs) derived from murine rod photoreceptors. The retinoblastoma epigenome mapped to the developmental stage when retinal progenitors switch from neurogenic to terminal patterns of cell division. The epigenome of retinoblastomas was more similar to that of the normal retina than that of retina-derived iPSCs, and we identified retina-specific epigenetic memory.

Original languageEnglish (US)
Pages (from-to)550-568.e10
Issue number3
StatePublished - May 3 2017
Externally publishedYes


  • DNA methylation
  • epigenetic memory
  • epigenetics
  • iPSCs
  • retinal development
  • retinoblastoma
  • rod photoreceptors

ASJC Scopus subject areas

  • General Neuroscience


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