The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation

Kristine S Vogel, Alun M. Davies

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

To investigate how the onset of neurotrophic factor dependence in neurons is coordinated with the arrival of their axons in the target field, we have studied the survival of four populations of cranial sensory neurons whose axons reach their common central target field, the hindbrain, at different times. We show that neurons whose axons reach the hindbrain first survive for a short time in culture before responding to brain-derived neurotrophic factor (BDNF). Neurons whose axons reach the hindbrain later survive longer before responding to BDNF. These differences in survival, which arise prior to gangliogenesis, may play a role in coordinating trophic interactions for cranial sensory neurons.

Original languageEnglish (US)
Pages (from-to)819-830
Number of pages12
JournalNeuron
Volume7
Issue number5
DOIs
StatePublished - 1991
Externally publishedYes

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Nerve Growth Factors
Sensory Receptor Cells
Rhombencephalon
Axons
Brain-Derived Neurotrophic Factor
Neurons
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation. / Vogel, Kristine S; Davies, Alun M.

In: Neuron, Vol. 7, No. 5, 1991, p. 819-830.

Research output: Contribution to journalArticle

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