@article{4b5c2f266b3b4cf78fde86a274e648a0,
title = "The downregulation of IL-18R defines bona fide kidney-resident CD8+ T cells",
abstract = "Immunology; Cell Biology; Transcriptomics",
keywords = "Cell Biology, Immunology, Transcriptomics",
author = "Wei Liao and Yong Liu and Chaoyu Ma and Liwen Wang and Guo Li and Shruti Mishra and Saranya Srinivasan and Fan, {Kenneth Ka Ho} and Haijing Wu and Qianwen Li and Ming Zhao and Xun Liu and Demel, {Erika L.} and Xin Zhang and Yuanzheng Qiu and Qianjin Lu and Nu Zhang",
note = "Funding Information: We thank Dr. Tessa Bergsbaken (Rutgers New Jersey Medical School) and Dr. Linda Wakim (University of Melbourne, Australia) for critical reading of the manuscript, Dr. Haihui Xue (Hackensack University Medical Center) for providing Tcf7-GFP retroviral vector, and Dr. Linxi Li (University of Arkansas for Medical Sciences) for help with parabiosis experiments. This work is supported by NIH grants AI125701 and AI139721, Cancer Research Institute CLIP program, and American Cancer Society grant RSG-18-222-01-LIB to N.Z. and National Natural Science Foundation of China (No. 81522038, No. 81270024, and No. 81220108017) to Q.L. We thank Dr. Ben Daniel and Karla Gorena for FACS sorting. Flow Cytometry data was generated in the UT Health San Antonio Flow Cytometry Shared Resource Facility, which is supported in part by UT Health San Antonio, the Mays Cancer Center P30 Cancer Center Support Grant (NIH-NCI P30 CA054174) and the NIH National Center for Advancing Translational Sciences Clinical Translational Science Award (NIH-NCATS UL1 TR002645). We thank Drs. Zhao Lai, Yi Zou and Yidong Chen for RNA-seq analysis and informatics assistance. RNA-seq analysis was performed by the Genome Sequencing Core Facility at UTHSCSA, which is supported by NIH/NCI Cancer Center Support Grant P30 CA054174, NIH Shared Instrument grant 1S10OD021805-01, and Cancer Prevention and Research Institute of Texas (CPRIT) Core Facility grant RP160732. Special thanks to Dr. Rizi Ai (UCSD) for suggestions and help on bioinformatics. Conceptualization, W.L. Y.L. Q.L. and N.Z.; Methodology, C.M. and X. L.; Investigation, W.L. Y.L. C.M. L.W. G.L. S.M. S.S. K.K-H.F. H.W. Q.L. M.Z. and E.L.D.; Writing?Original Draft, W.L. Q.L. X.Z. Y.Q. and N.Z.; Writing?Review & Editing, N.Z.; Supervision, Q.L. and N.Z.; Funding Acquisition, Q.L. and N.Z. The authors declare no competing interests. Funding Information: We thank Dr. Tessa Bergsbaken (Rutgers New Jersey Medical School) and Dr. Linda Wakim (University of Melbourne, Australia) for critical reading of the manuscript, Dr. Haihui Xue (Hackensack University Medical Center) for providing Tcf7-GFP retroviral vector, and Dr. Linxi Li (University of Arkansas for Medical Sciences) for help with parabiosis experiments. This work is supported by NIH grants AI125701 and AI139721 , Cancer Research Institute CLIP program, and American Cancer Society grant RSG-18-222-01-LIB to N.Z. and National Natural Science Foundation of China (No. 81522038 , No. 81270024 , and No. 81220108017 ) to Q.L. We thank Dr. Ben Daniel and Karla Gorena for FACS sorting. Flow Cytometry data was generated in the UT Health San Antonio Flow Cytometry Shared Resource Facility, which is supported in part by UT Health San Antonio, the Mays Cancer Center P30 Cancer Center Support Grant ( NIH-NCI P30 CA054174 ) and the NIH National Center for Advancing Translational Sciences Clinical Translational Science Award ( NIH-NCATS UL1 TR002645 ). We thank Drs. Zhao Lai, Yi Zou and Yidong Chen for RNA-seq analysis and informatics assistance. RNA-seq analysis was performed by the Genome Sequencing Core Facility at UTHSCSA, which is supported by NIH/ NCI Cancer Center Support Grant P30 CA054174 , NIH Shared Instrument grant 1S10OD021805-01 , and Cancer Prevention and Research Institute of Texas ( CPRIT ) Core Facility grant RP160732 . Special thanks to Dr. Rizi Ai (UCSD) for suggestions and help on bioinformatics. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2021",
month = jan,
day = "22",
doi = "10.1016/j.isci.2020.101975",
language = "English (US)",
volume = "24",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "1",
}