The double corpus luteum: A novel sonographic sign of heterotopic pregnancy

Matthew L. Kluckman, Ryan B. Schwope, Alyssa J. Provagna, Belinda J. Yauger, Christina I. Ramirez

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Heterotopic pregnancy is a rare and highly morbid condition with simultaneous intrauterine and extra-uterine pregnancies. The early diagnosis of heterotopic pregnancy is difficult, owing to rarity of the condition and nonspecific clinical and laboratory findings. This case report introduces the “double corpus luteum” sign, a new sonographic and magnetic resonance imaging sign which is easily detectable and should raise the index of suspicion for heterotopic pregnancy. We present a surgically confirmed spontaneous heterotopic and angular pregnancy in a young woman without risk factors or assisted reproductive therapy to illustrate the utility of this novel sign.

Original languageEnglish (US)
Pages (from-to)617-621
Number of pages5
JournalJournal of Clinical Ultrasound
Issue number6
StatePublished - Jul 1 2021
Externally publishedYes


  • double corpus luteum
  • first trimester bleeding
  • heterotopic pregnancy
  • obstetrics
  • ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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