The Diverse Roles of RNA-Binding Proteins in Glioma Development

Mitzli X. Velasco, Adam Kosti, Luiz O Penalva, Greco Hernández

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Post-transcriptional regulation of gene expression is fundamental for all forms of life, as it critically contributes to the composition and quantity of a cell’s proteome. These processes encompass splicing, polyadenylation, mRNA decay, mRNA editing and modification and translation and are modulated by a variety of RNA-binding proteins (RBPs). Alterations affecting RBP expression and activity contribute to the development of different types of cancer. In this chapter, we discuss current research shedding light on the role of different RBPs in gliomas. These studies place RBPs as modulators of critical signaling pathways, establish their relevance as prognostic markers and open doors for new therapeutic strategies.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages29-39
Number of pages11
DOIs
StatePublished - Jan 1 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1157
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • ADARs
  • Cancer
  • Glioblastoma
  • hnRNP
  • HuR
  • IGF2BPs
  • Musashi1
  • PTBP
  • RNA-binding proteins
  • Translation initiation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Velasco, M. X., Kosti, A., Penalva, L. O., & Hernández, G. (2019). The Diverse Roles of RNA-Binding Proteins in Glioma Development. In Advances in Experimental Medicine and Biology (pp. 29-39). (Advances in Experimental Medicine and Biology; Vol. 1157). Springer New York LLC. https://doi.org/10.1007/978-3-030-19966-1_2