The Diverse Roles of RNA-Binding Proteins in Glioma Development

Mitzli X. Velasco, Adam Kosti, Luiz O.F. Penalva, Greco Hernández

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations


Post-transcriptional regulation of gene expression is fundamental for all forms of life, as it critically contributes to the composition and quantity of a cell’s proteome. These processes encompass splicing, polyadenylation, mRNA decay, mRNA editing and modification and translation and are modulated by a variety of RNA-binding proteins (RBPs). Alterations affecting RBP expression and activity contribute to the development of different types of cancer. In this chapter, we discuss current research shedding light on the role of different RBPs in gliomas. These studies place RBPs as modulators of critical signaling pathways, establish their relevance as prognostic markers and open doors for new therapeutic strategies.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Number of pages11
StatePublished - 2019

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • ADARs
  • Cancer
  • Glioblastoma
  • HuR
  • IGF2BPs
  • Musashi1
  • PTBP
  • RNA-binding proteins
  • Translation initiation
  • hnRNP

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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