TY - JOUR
T1 - The disutility of chronic gout
AU - Khanna, Dinesh
AU - Ahmed, Mansoor
AU - Yontz, Dustin
AU - Ginsburg, Shaari S.
AU - Park, Grace S.
AU - Leonard, Anthony
AU - Tsevat, Joel
N1 - Funding Information:
Acknowledgements Dr. Khanna was supported by a National Institutes of Health Award (NIAMS K23 AR053858-01A1). Mr. Yontz was supported by a grant from the American Federation of Aging, Ohio Chapter. Dr. Tsevat was supported in part by a National Center for Complementary and Alternative Medicine award (grant # K24 AT001676). TAP Pharmaceuticals Products Inc. provided funding for the study but had no role in data collection, analysis, manuscript preparation, and the decision to submit the manuscript for publication.
PY - 2008/6
Y1 - 2008/6
N2 - Introduction: Gout is a chronic painful inflammatory arthritis. Data regarding the impact of gout on health-related quality of life, however, are limited. Methods: We interviewed patients with chronic stable gout. Health status was measured by using the Short Form 36 (SF-36) physical component summary (PCS) and physical component summary (MCS) and the Health Assessment Questionnaire-Disability Index (HAQ-DI). Direct preference-based measures included a health rating scale (RS), the time tradeoff (TTO), and standard gamble (SG) for one's current health state with gout and current health state without gout; indirect preference-based measures included the SF-6D and the EQ-5D. Disutilities for gout were assessed by subtracting preference scores for current health states with gout from those for current health without gout and were compared between patients ranking gout as their top health concern versus the rest of the patients. Results: Of the 80 interviewees, 72 (90%) were male, 55 (69%) were Caucasian, and the mean (SD) age was 60 (11) years. The mean SF-36 PCS and MCS scores were 38.9 and 48.6, respectively. The mean (SD) SF-6D score was 0.68 (0.13) and the mean (SD) EQ-5D score was 0.73 (0.23). The mean (SD) RS disutility for gout was 0.05 (0.12), the mean TTO disutility was 0.03 (0.12), and the mean SG disutility was 0.02 (0.11). The RS disutilities of subject patients who ranked gout as their top concern (n = 17) trended towards being statistically significantly larger than those of the remaining patients, P = 0.06 but their TTO and SG disutilities were similar to those of the remaining patients. Conclusion: Although physical functioning of patients with gout is often compromised, patients with chronic stable gout do not assign a large disutility to gout per se. Still, patients who rank their gout as their top health concern tend to assign greater RS disutility to gout than do other patients.
AB - Introduction: Gout is a chronic painful inflammatory arthritis. Data regarding the impact of gout on health-related quality of life, however, are limited. Methods: We interviewed patients with chronic stable gout. Health status was measured by using the Short Form 36 (SF-36) physical component summary (PCS) and physical component summary (MCS) and the Health Assessment Questionnaire-Disability Index (HAQ-DI). Direct preference-based measures included a health rating scale (RS), the time tradeoff (TTO), and standard gamble (SG) for one's current health state with gout and current health state without gout; indirect preference-based measures included the SF-6D and the EQ-5D. Disutilities for gout were assessed by subtracting preference scores for current health states with gout from those for current health without gout and were compared between patients ranking gout as their top health concern versus the rest of the patients. Results: Of the 80 interviewees, 72 (90%) were male, 55 (69%) were Caucasian, and the mean (SD) age was 60 (11) years. The mean SF-36 PCS and MCS scores were 38.9 and 48.6, respectively. The mean (SD) SF-6D score was 0.68 (0.13) and the mean (SD) EQ-5D score was 0.73 (0.23). The mean (SD) RS disutility for gout was 0.05 (0.12), the mean TTO disutility was 0.03 (0.12), and the mean SG disutility was 0.02 (0.11). The RS disutilities of subject patients who ranked gout as their top concern (n = 17) trended towards being statistically significantly larger than those of the remaining patients, P = 0.06 but their TTO and SG disutilities were similar to those of the remaining patients. Conclusion: Although physical functioning of patients with gout is often compromised, patients with chronic stable gout do not assign a large disutility to gout per se. Still, patients who rank their gout as their top health concern tend to assign greater RS disutility to gout than do other patients.
KW - Gout
KW - Health status
KW - Health utility
KW - Health-related quality of life
KW - Preference-based measures
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U2 - 10.1007/s11136-008-9355-0
DO - 10.1007/s11136-008-9355-0
M3 - Article
C2 - 18500578
AN - SCOPUS:49949152075
SN - 0962-9343
VL - 17
SP - 815
EP - 822
JO - Quality of Life Research
JF - Quality of Life Research
IS - 5
ER -